{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:27:07Z","timestamp":1788251227559,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia\u2010related parameters may have differential impacts on health\u2010related outcomes in older adults. We examined dose\u2013response relationships of body composition, muscle strength, and physical performance with incident disability and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study included 1765 Japanese residents (862 men; 903 women) aged \u226565\u00a0years who participated in health check\u2010ups. Outcomes were incident disability and all\u2010cause mortality. Fat mass index (FMI) and skeletal muscle mass index (SMI), determined using segmental multi\u2010frequency bioelectrical impedance analysis, handgrip strength (HGS), and usual gait speed (UGS) were measured. We determined multivariate\u2010adjusted hazard ratios (HRs) for disability and mortality relative to sex\u2010specific reference values (FMI: medians; SMI: 7.0\u00a0kg\/m<jats:sup>2<\/jats:sup> for men and 5.7\u00a0kg\/m<jats:sup>2<\/jats:sup> for women; HGS: 28\u00a0kg for men and 18\u00a0kg for women; or UGS: 1.0\u00a0m\/s for both sexes). Association shapes were examined using restricted cubic splines or fractional polynomial functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 5.3\u00a0years; 107 (12.7%) men and 123 (14.2%) women developed disability, and 101 (11.7%) men and 56 (6.2%) women died. FMI did not impact any outcome in men and disability in women, while an FMI\u00a0\u2264\u00a07.3\u00a0kg\/m<jats:sup>2<\/jats:sup> (median) was significantly associated with higher mortality risk in women, compared with median FMI. SMI did not impact disability in either sex and mortality in women, but showed a significant inverse dose\u2013response relationship with mortality risk in men [HRs (95% confidence intervals) of minimum and maximum values compared with the reference value: 2.18 (1.07\u20134.46) and 0.43 (0.20\u20130.93), respectively], independent of HGS and UGS. HGS and UGS showed a significant inverse dose\u2013response relationship with disability in both sexes [HGS: 1.71 (1.00\u20132.91) and 0.31 (0.09\u20130.99), respectively, in men, 2.42 (1.18\u20134.96) and 0.41 (0.20\u20130.85), respectively, in women; UGS: 2.14 (1.23\u20133.74) and 0.23 (0.08\u20130.67), respectively, in men, 3.26 (2.07\u20135.14) and 0.11 (0.05\u20130.26), respectively, in women] and mortality in women [HGS: 6.84 (2.84\u201316.47) and 0.06 (0.02\u20130.21), respectively; UGS: 2.67 (1.14\u20136.27) and 0.30 (0.11\u20130.85), respectively], independent of body composition, but did not impact mortality in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Disability risk was more dependent on muscle strength and physical performance in both sexes. Mortality risk in men was more dependent on muscle mass, and mortality risk in women was influenced by lower fat mass along with muscle strength and physical performance. Although improving muscle strength and physical performance should be the first target for health promotion, it is also necessary to pay attention to body composition to extend life expectancy in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12958","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:36:13Z","timestamp":1645781773000},"page":"932-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dose\u2013response relationships of sarcopenia parameters with incident disability and mortality in older Japanese adults"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-8730","authenticated-orcid":false,"given":"Satoshi","family":"Seino","sequence":"first","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute of Gerontology  Tokyo 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Japan"},{"name":"Center for Health and Environmental Risk Research National Institute for Environmental Studies  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Murayama","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Amano","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Nishi","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute of Gerontology  Tokyo 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