{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:42:47Z","timestamp":1791909767492,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is an age\u2010related chronic condition that can lead to mobility disabilities. This study aimed to evaluate the risk factors for incident sarcopenia in older Korean adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Korean Frailty and Aging Cohort Study (KFACS) is a multicentre prospective study with a baseline examination in 2016\u20132017. A prospective follow\u2010up study was conducted in 2018\u20132019. Changes in muscle\u2010related variables were evaluated for subjects aged 70\u201384\u00a0years lacking sarcopenia at baseline. Sarcopenia was diagnosed according to the 2019 updated Asian Working Group for Sarcopenia consensus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1636 participants (54.4% women, age 75.9\u00a0\u00b1\u00a03.7) who did not have sarcopenia at baseline, 101 men (13.5%) and 104 women (11.7%) developed sarcopenia by the follow\u2010up. Those who developed sarcopenia were older (men, 77.9\u00a0\u00b1\u00a03.9 vs. 75.7\u00a0\u00b1\u00a03.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; women, 77.5\u00a0\u00b1\u00a04.0 vs. 75.5\u00a0\u00b1\u00a03.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) with a lower body mass index at baseline (men, 23.9\u00a0\u00b1\u00a02.4 vs. 24.5\u00a0\u00b1\u00a02.9\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.025; women, 23.7\u00a0\u00b1\u00a02.8 vs. 25.2\u00a0\u00b1\u00a02.9\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with older adults who remained nonsarcopenic; levels of glycated haemoglobin (men, 6.2\u00a0\u00b1\u00a01.0% vs. 5.9\u00a0\u00b1\u00a00.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.029) and the homeostasis model assessment of insulin resistance (men, 2.0\u00a0\u00b1\u00a01.3 vs. 1.7\u00a0\u00b1\u00a01.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.022) were higher in men who progressed to sarcopenia but not in women. Development of sarcopenia was associated with older age and the frequency of resistance training (\u22652 per week) after adjusting for potential risk factors in men [age, odds ratio (OR) 1.17, 95% confidence interval (CI) 1.10\u20131.25; frequent resistance training, OR 0.50, 95% CI 0.30\u20130.82]. In women, advanced age, poor nutritional status, and physical inactivity contributed to the development of sarcopenia (age, OR 1.14, 95% CI 1.08\u20131.21; mini nutritional assessment short form, OR 0.79, 95% CI 0.70\u20130.90; moderate to high physical activity, OR 0.57, 95% CI 0.34\u20130.95).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this 2\u00a0year KFACS follow\u2010up, modifiable risk factors for incident sarcopenia differed between genders. Resistance training (\u22652 per week) helped to prevent sarcopenia in these community\u2010dwelling older men. In older women, adequate nutritional support and being physically active might play a role in preventing progression to sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12993","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:21:45Z","timestamp":1648797705000},"page":"1908-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Gender differences in risk factors for the 2\u00a0year development of sarcopenia in community\u2010dwelling older adults"],"prefix":"10.1002","volume":"13","author":[{"given":"Hun Jee","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be Long","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Health Promotion and Optimal Aging Seoul National University College of Medicine and Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chuncheon Sacred Heart Hospital Hallym University College of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Roh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Korea University Guro Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Jeju National University School of Medicine  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine Gyeongsang National University  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, College of Medicine, East\u2010West Medical Research Institute Kyung Hee University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Won","family":"Won","sequence":"additional","affiliation":[{"name":"Elderly Frailty Research Center, Department of Family Medicine, College of Medicine Kyung Hee University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Chul","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"KOSTAT.Explore Korea through Statistics 2020.https:\/\/kostat.go.kr\/portal\/korea\/kor_nw\/1\/1\/index.board?bmode=read&aSeq=403253. 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