{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:45:46Z","timestamp":1789443946590,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite medical advances, septic shock remains one of the main causes of high mortality in critically ill patients. Although sarcopenia is considered a predictor of mortality in septic shock patients, most studies have only investigated short\u2010term mortality, and those on long\u2010term prognosis are limited. We investigated the impact of sarcopenia on long\u2010term mortality in a large patient population with septic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study comprising 905 patients with septic shock was conducted from 2008 to 2019. Sarcopenia was defined based on the measurement of the total abdominal muscle area, assessed using abdominal computed tomography scans. Thereafter, we stratified the patients into two groups\u2014sarcopenia and non\u2010sarcopenia groups\u2014and compared the impact of sarcopenia on short\u2010term (28\u00a0days) and long\u2010term (1\u00a0year and overall) mortality using multivariable Cox proportional analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 905 patients were included, and the mean age was 65.7\u00a0\u00b1\u00a015.1\u00a0years. Among them, 430 (47.5%) patients were male and 407 (45.0%) had sarcopenia. We found that the 28\u00a0day, 1\u00a0year, and overall mortality rates in the sarcopenia group were significantly higher than those in the non\u2010sarcopenia group (13.8% vs. 6.4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; 41.8% vs. 21.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; 62.2% vs. 35.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, respectively). Univariable Cox analysis showed that the sarcopenia group had a significant association with the increase in each mortalities compared with the non\u2010sarcopenia group (28\u00a0day mortality, hazard ratio (HR)\u00a0=\u00a02.230, 95% confidence interval (CI) [1.444\u20133.442], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; 1\u00a0year mortality, HR\u00a0=\u00a02.189, 95% CI [1.720, 2.787], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; overall mortality, HR\u00a0=\u00a02.254, 95% CI [1.859, 2.734], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Multivariable Cox analysis showed that both the short\u2010term and long\u2010term mortality rates remained significantly higher in the sarcopenia group than in the non\u2010sarcopenia group, even after adjusting for confounding variables (28\u00a0day mortality, HR\u00a0=\u00a02.116, 95% CI [1.312, 3.412], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002; 1\u00a0year mortality, HR\u00a0=\u00a01.679, 95% CI [1.291, 2.182], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; overall mortality, HR\u00a0=\u00a01.704, 95% CI [1.381, 2.102], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia was associated with both short\u2010term and long\u2010term mortality in patients with septic shock. In clinical settings, close attention should be paid to these patients for both short\u2010term and long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12995","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T02:29:12Z","timestamp":1651112952000},"page":"2054-2063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The impact of sarcopenia on short\u2010term and long\u2010term mortality in patients with septic shock"],"prefix":"10.1002","volume":"13","author":[{"given":"Hyung Jung","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Nephrology Sheikh Khalifa Specialty Hospital  Ras al Khaimah United Arab Emirates"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Rim","family":"Kim","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-4327","authenticated-orcid":false,"given":"Nam Su","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon\u2010Sup","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Goo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine  Seoul Seodaemun\u2010gu 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