{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:25:47Z","timestamp":1780611947115,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancer cachexia (CC) is a severe complication during the last stages of the disease, which is characterized by the substantial loss of muscle and fat mass. Currently, there is no effective treatment of CC. Erythropoietin plays tissue\u2010protective role in different tissues. Based on the structure of erythropoietin, small non\u2010erythropoietic peptides were synthesized, which activate tissue\u2010protective signalling pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we investigated the influence of the tissue\u2010protective peptide ARA 284 on CC in rats using the Yoshida hepatoma model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with ARA 284 (1.7\u00a0\u03bcg\/kg\/day) counteracted the loss of body weight (12.46\u00a0\u00b1\u00a04.82% ARA 284 vs. 26.85\u00a0\u00b1\u00a00.88% placebo, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), fat mass (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and lean mass (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). It improved spontaneous activity of ARA 284\u2010treated animals. Further, gastrocnemius mass was increased (13.2% ARA 284 vs. placebo, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) in association with induced p\u2010Akt (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and decreased in p\u2010p38 MAPK, GSK\u20103\u03b2, and myostatin (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), suggesting an induction of anabolic pathways. At the same time, we observed the significant increase in the survival of animals by high\u2010dose ARA 284 treatment (hazard ratio: 0.46, 95% confidence interval: 0.23\u20130.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0325).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together these results suggest that ARA 284 can be considered beneficial in experimental CC and it remains to be seen, if it can have similar beneficial effects in CC patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13009","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T06:26:28Z","timestamp":1652941588000},"page":"2202-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The erythropoietin\u2010derived peptide ARA 284 reduces tissue wasting and improves survival in a rat model of cancer cachexia"],"prefix":"10.1002","volume":"13","author":[{"given":"Sandra","family":"Palus","sequence":"first","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Elkina","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Braun","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"D\u00f6hner","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Centre for Stroke Research Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Cerami","sequence":"additional","affiliation":[{"name":"ARAIM Pharmaceuticals  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