{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:21:21Z","timestamp":1791213681937,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinically meaningful changes in the five\u2010repetition chair stand test are essential for monitoring mobility in integrated care for older people. Recommendations for the clinically meaningful change of the chair stand test are not well known. Our study aimed to estimate the absolute and relative clinically meaningful changes for older adults' five\u2010repetition chair stand test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied distribution\u2010based and anchor\u2010based methods in addition to receiver operator characteristics analyses to a population\u2010based study of community\u2010dwelling adults (SAGE Mexico study, <jats:italic>n<\/jats:italic>\u00a0=\u00a0897) to derive the clinically meaningful change in the chair stand test. We used three self\u2010reported clinical anchors: moving around, vigorous activities, and walking 1\u00a0km. Our primary outcome was the incidence of disability for basic activities of daily living (ADL). Secondly, we examined our estimates of clinically meaningful change in a clinical trial population of healthy volunteers (MAPT, France, study <jats:italic>n<\/jats:italic>\u00a0=\u00a01575) concerning the risk of incident ADL disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age of SAGE Mexico participants ranged from 60 to 96\u00a0years; mean (SD)\u00a0=\u00a069.0 (6.2); 54.4% were female. Their baseline chair stand time averaged 12.1\u00a0s (SD\u00a0=\u00a03\u00a0s). Forty\u2010eight participants (5.6%) showed incident disability over 3\u00a0years. The absolute and relative clinically meaningful change cut points found over 3\u00a0years of follow\u2010up were 2.6\u00a0s and 27.7%, respectively. Absolute clinically meaningful change ranged from 0.5 to 4.7\u00a0s, depending on the estimation method. Relative clinically meaningful change ranged from 9.6 to 46.2%. SAGE Mexico participants with absolute and relative clinically meaningful declines (increasing 2.6\u00a0s and 27.7% from baseline time, respectively) showed an increased risk of ADL disability [aRR\u00a0=\u00a01.93; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0381; 95% CI (1.05, 3.46) and aRR\u00a0=\u00a02.27; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0157; 95% CI (1.22, 4.10)], respectively, compared with those without a clinically meaningful decline. MAPT participants [age range\u00a0=\u00a070\u201394; mean (SD)\u00a0=\u00a075.3 (4.4); 64.8% female; incident ADL disability over 5\u00a0years\u00a0=\u00a0145(14.8%)] with a relative clinically meaningful decline (\u226527.7% from baseline over 3\u00a0years) had a 74% higher risk of incident ADL disability than their counterparts [aHR\u00a0=\u00a01.74; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016; CI95% (1.11, 2.72); mean follow\u2010up of 58\u00a0months].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Community\u2010dwelling older adults with an increase of 3\u00a0s or 28% in chair stand test performance over 3\u00a0years (approximately 1\u00a0s or 10% per year) could be the target of interventions to enhance mobility and prevent incident disability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13042","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T09:49:04Z","timestamp":1661507344000},"page":"2331-2339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Clinically meaningful change for the chair stand test: monitoring mobility in integrated care for older people"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-3034","authenticated-orcid":false,"given":"Emmanuel","family":"Gonzalez\u2010Bautista","sequence":"first","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Salinas\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Center for Surveys and Evaluation Research National Institute of Public Health (INSP) Mexico  Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Manrique\u2010Espinoza","sequence":"additional","affiliation":[{"name":"Center for Surveys and Evaluation Research National Institute of Public Health (INSP) Mexico  Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Andrieu","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MAPT\/DSA 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