{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:58Z","timestamp":1792099858303,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20102013"],"award-info":[{"award-number":["FP7\/2007\u20102013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frailty and sarcopenia are age\u2010associated syndromes that have been associated with the risk of several adverse events, mainly functional decline and death, that usually coexist. However, the potential role of one of them (sarcopenia) in modulating some of those adverse events associated to the other one (frailty) has not been explored. The aim of this work is to assess the role of sarcopenia within the frailty transitions and mortality in older people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Toledo Study of Healthy Aging (TSHA) were used. TSHA is a cohort of community\u2010dwelling older adults \u226565. Frailty was assessed according with the Frailty Phenotype (FP) and the Frailty Trait Scale\u20105 (FTS5) at baseline and at follow\u2010up. Basal sarcopenia status was measured with the standardized Foundation for the National Institutes of Health criteria. Fisher's exact test and logistic regression model were used to determine if sarcopenia modified the transition of frailty states (median follow\u2010up of 2.99\u00a0years) and Cox proportional hazard model was used for assessing mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1538 participants (74.73\u00a0\u00b1\u00a05.73; 45.51% men) included. Transitions from robustness to prefrailty and frailty according to FP were more frequent in sarcopenic than in non\u2010sarcopenic participants (32.37% vs. 15.18%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001; 5.76% vs. 1.12%; <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001, respectively) and from prefrailty\u2010to\u2010frailty (12.68% vs. 4.27%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0026). Improvement from prefrail\u2010to\u2010robust and remaining robust was more frequent in non\u2010sarcopenic participants (52.56% vs. 33.80%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001; 80.18% vs 61.15%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001, respectively). When classified by FTS5, this was also the case for the transition from non\u2010frail\u2010to\u2010frail (25.91% vs. 4.47%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001) and for remaining stable as non\u2010frail (91.25% vs. 70.98%, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001). Sarcopenia was associated with an increased risk of progression from robustness\u2010to\u2010prefrailty [odds ratio (OR) 2.34 (95% confidence interval, CI) (1.51, 3.63); <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001], from prefrailty\u2010to\u2010frailty [OR(95% CI) 2.50 (1.08, 5.79); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.033] (FP), and from non\u2010frail\u2010to\u2010frail [OR(95% CI) 4.73 (2.94, 7.62); <jats:italic>P<\/jats:italic>\u2010value\u00a0\u2264\u00a00.001]. Sarcopenia does not seem to modify the risk of death associated with a poor frailty status (hazard ratios (HR, 95%) <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transitions within frailty status, but not the risk of death associated to frailty, are modulated by the presence of sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13055","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:39:52Z","timestamp":1659076792000},"page":"2352-2360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Role of sarcopenia in the frailty transitions in older adults: a population\u2010based cohort study"],"prefix":"10.1002","volume":"13","author":[{"given":"Alejandro","family":"\u00c1lvarez\u2010Bustos","sequence":"first","affiliation":[{"name":"CIBER of Frailty and Healthy Ageing, CIBERFES Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Carnicero\u2010Carre\u00f1o","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Ageing, CIBERFES Instituto de Salud Carlos III  Madrid Spain"},{"name":"Biomedical Research Foundation Getafe University Hospital, Carretera de Toledo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Davies","sequence":"additional","affiliation":[{"name":"Geriatrics Department Getafe University Hospital, Carretera de Toledo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Garcia\u2010Garcia","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Ageing, CIBERFES Instituto de Salud Carlos III  Madrid Spain"},{"name":"Virgen del Valle Hospital Carretera de Cobisa  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez\u2010Artalejo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Universidad Aut\u00f3noma de Madrid\/IdiPaz  Madrid Spain"},{"name":"CIBER of Epidemiology and Public Health CIBERESP Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1333","authenticated-orcid":false,"given":"Leocadio","family":"Rodr\u00edguez\u2010Ma\u00f1as","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Ageing, CIBERFES Instituto de Salud Carlos III  Madrid Spain"},{"name":"Geriatrics Department Getafe University Hospital, Carretera de Toledo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alonso\u2010Bouz\u00f3n","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy 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