{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:39:42Z","timestamp":1785159582542,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560240"],"award-info":[{"award-number":["81560240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770485"],"award-info":[{"award-number":["81770485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Young bone marrow transplantation (YBMT) has been shown to stimulate vascular regeneration in pathological conditions, including ageing. Here, we investigated the benefits and mechanisms of the preventive effects of YBMT on loss of muscle mass and function in a senescence\u2010associated mouse prone 10 (SAMP10) model, with a special focus on the role of growth differentiation factor 11 (GDF\u201011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine\u2010week\u2010old male SAMP10 mice were randomly assigned to a non\u2010YBMT group (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and a YBMT group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) that received the bone marrow of 8\u2010week\u2010old C57BL\/6 mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the non\u2010YBMT mice, the YBMT mice showed the following significant increases (all P &lt; 0.05 in 6\u20137 mice): endurance capacity (&gt;61.3%); grip strength (&gt;37.9%), percentage of slow myosin heavy chain fibres (&gt;14.9\u201315.9%). The YBMT also increased the amounts of proteins or mRNAs for insulin receptor substrate 1, p\u2010Akt, p\u2010extracellular signal\u2010regulated protein kinase1\/2, p\u2010mammalian target of rapamycin, Bcl\u20102, peroxisom proliferator\u2010activated receptor\u2010\u03b3 coactivator (PGC\u20101\u03b1), plus cytochrome c oxidase IV and the numbers of proliferating cells (n = 5\u20137, P &lt; 0.05) and CD34+\/integrin\u2010\u03b17+ muscle stem cells (n = 5\u20136, P &lt; 0.05). The YMBT significantly decreased the levels of gp91phox, caspase\u20109 proteins and apoptotic cells (n = 5\u20137, P &lt; 0.05) in both muscles; these beneficial changes were diminished by the blocking of GDF\u201011 (n = 5\u20136, P &lt; 0.05). An administration of mouse recombinant GDF\u201011 improved the YBMT\u2010mediated muscle benefits (n = 5\u20136, P &lt; 0.05). Cell therapy with young bone marrow from green fluorescent protein (GFP) transgenic mice exhibited GFP+ myofibres in aged muscle tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that YBMT can prevent muscle wasting and dysfunction by mitigating apoptosis and proliferation via a modulation of GDF\u201011 signalling and mitochondrial dysfunction in SAMP10 mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13058","type":"journal-article","created":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T21:05:25Z","timestamp":1662325525000},"page":"3078-3090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Young bone marrow transplantation prevents aging\u2010related muscle atrophy in a senescence\u2010accelerated mouse prone 10 model"],"prefix":"10.1002","volume":"13","author":[{"given":"Aiko","family":"Inoue","sequence":"first","affiliation":[{"name":"Institute of Innovation for Future Society Nagoya University Graduate School of Medicine  Nagoya Aichiken Japan"},{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Aichiken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Piao","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Human Cord Applied Cell Therapy Nagoya University Graduate School of Medicine  Nagoya Aichiken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health Guilin Medical College  Guilin Guangxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital Fudan University  Shanghai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangkun","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Aichiken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Hamamatsu University School of Medicine  Hamamatsu Shizuokaken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Itakura","sequence":"additional","affiliation":[{"name":"Division for Medical Research Engineering Nagoya University Graduate School of Medicine  Nagoya Aichiken 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Wu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0570-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0131-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12166"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00108"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-018-0509-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2020.11.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1051-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0589-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02928-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0993-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073645"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.909218"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3465"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000260801.12916.b5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.10.022"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307521"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv385"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251152"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.015"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251141"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.010"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00152"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171028"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12248"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4838"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328341cedf"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002418"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3464"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02530-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6938620"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08991"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr037"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1015-7"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55330-6_22"},{"key":"e_1_2_8_39_1","article-title":"Integrative 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