{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:33:14Z","timestamp":1781951594138,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advanced chronic kidney disease is associated with muscle wasting, but how glomerular filtration rate (GFR) recovery after kidney transplantation is associated with muscle mass is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We took advantage of the simultaneous measurement of GFR (using iohexol plasma clearance; ioGFR) and creatinine excretion rate (a surrogate marker of muscle mass; CER) performed 3\u00a0months after transplantation and at a later time point at our institution to investigate the interplay between allograft function, muscle mass, and outcome in kidney transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between June 2005 and October 2019, 1319 successive kidney transplant recipients (mean age 50.4\u00a0\u00b1\u00a014.6; 38.7% female) underwent GFR measurement at our institution 3\u00a0months after kidney transplantation. CER (CER<jats:sub>3<\/jats:sub>) and ioGFR (ioGFR<jats:sub>3<\/jats:sub>) were 7.7\u00a0\u00b1\u00a02.6\u00a0\u03bcmol\/min and 53\u00a0\u00b1\u00a017.1\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, respectively. Multivariable analysis identified female gender, older donor and recipient age, reduced body mass index, coronary disease, dialysis history, proteinuria, and reduced ioGFR<jats:sub>3<\/jats:sub> as independent predictors of low CER<jats:sub>3<\/jats:sub> (ioGFR<jats:sub>3<\/jats:sub>: <jats:italic>\u03b2<\/jats:italic> coefficient 0.19 [95% confidence interval 0.14 to 0.24]). A total of 1165 patients had a subsequent CER measurement after a median follow\u2010up of 9.5\u00a0months. Of them, 373 (32%) experienced an increase in CER\u00a0&gt;\u00a010%, while 222 (19%) showed a CER decrease of more than 10%. Multivariable analysis adjusted for CER<jats:sub>3<\/jats:sub> and other confounders identified ioGFR<jats:sub>3<\/jats:sub> as an independent predictor of CER at follow\u2010up (<jats:italic>\u03b2<\/jats:italic> coefficient 0.11 [95% confidence interval 0.07 to 0.16]). In multivariable Cox analysis, reduced CER at 3\u00a0months or at follow\u2010up were consistently associated with mortality (hazard ratio [95% confidence interval] at 3\u00a0months: 0.82 [0.74 to 0.91]; at follow\u2010up: 0.79 [0.69 to 0.99]) but not with graft loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glomerular filtration rate recovery is a determinant of muscle mass variation after kidney transplantation. Early interventions targeting muscle mass gain may be beneficial for kidney transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13066","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T04:41:15Z","timestamp":1663216875000},"page":"2875-2887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Allograft function and muscle mass evolution after kidney transplantation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-8418","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Gaillard","sequence":"first","affiliation":[{"name":"Service de Transplantation, N\u00e9phrologie et Immunologie Clinique, H\u00f4pital Edouard Herriot et facult\u00e9 de m\u00e9decine Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Ould 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M\u00e9dical H\u00f4pital Necker\u2010Enfants Malades, Assistance\u2010Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine Universit\u00e9 de Paris\u2010Cit\u00e9  Paris France"},{"name":"Service de N\u00e9phrologie et Transplantation H\u00f4pital Necker\u2010Enfants Malades, Assistance\u2010Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Institut Necker\u2010Enfants Malades, INSERM U1151  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine Universit\u00e9 de Paris\u2010Cit\u00e9  Paris France"},{"name":"Service de N\u00e9phrologie et Transplantation H\u00f4pital Necker\u2010Enfants Malades, Assistance\u2010Publique\u2010H\u00f4pitaux de Paris  Paris 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