{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:31:50Z","timestamp":1791369110143,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG060110"],"award-info":[{"award-number":["R01AG060110"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative ageing\u2010related health outcomes. Given these links, grip strength has been labelled a \u2018biomarker of aging\u2019; and yet, the pathways connecting grip strength to negative health consequences are unclear. The objective of this study was to determine whether grip strength was associated with measures of DNA methylation (DNAm) age acceleration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Middle age and older adults from the 2006 to 2008 waves of the Health and Retirement Study with 8\u201310\u00a0years of follow\u2010up were included. Cross\u2010sectional and longitudinal regression modelling was performed to examine the association between normalized grip strength (NGS) and three measures of DNAm age acceleration, adjusting for cell composition, sociodemographic variables and smoking. Longitudinal modelling was also completed to examine the association between change in absolute grip strength and DNAm age acceleration. The three DNAm clocks used for estimating age acceleration include the established DunedinPoAm, PhenoAge and GrimAge clocks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a robust and independent cross\u2010sectional association between NGS and DNAm age acceleration for men using the DunedinPoAm (\u03b2: \u22120.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), PhenoAge (\u03b2: \u22128.27;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) and GrimAge (\u03b2: \u22124.56;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) clocks and for women using the DunedinPoAm (\u03b2: \u22120.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and GrimAge (\u03b2: \u22124.46;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) clocks. There was also an independent longitudinal association between baseline NGS and DNAm age acceleration for men (\u03b2: \u22120.26;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and women (\u03b2: \u22120.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) using the DunedinPoAm clock and for women only using the PhenoAge (\u03b2: \u22128.20;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and GrimAge (\u03b2: \u22125.91;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) clocks. Longitudinal modelling revealed a robust association between change in grip strength from wave 1 to wave 3 was independently associated with PhenoAgeAA (\u03b2: \u22120.13; 95% CI: \u22120.23, \u22120.03) and GrimAgeAA (\u03b2: \u22120.07; 95% CI: \u22120.14, \u22120.01) in men only (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide some initial evidence of age acceleration among men and women with lower NGS and loss of strength over time. Future research is needed to understand the extent to which DNAm age mediates the association between grip strength and chronic disease, disability and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13110","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:55:48Z","timestamp":1668048948000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Grip strength is inversely associated with DNA methylation age acceleration"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-4275","authenticated-orcid":false,"given":"Mark D.","family":"Peterson","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan  Ann Arbor MI USA"},{"name":"Michigan Institute for Health Policy and Innovation (IHPI)  Ann Arbor MI USA"},{"name":"Michigan Center on the Demography of Aging (MiCDA)  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Collins","sequence":"additional","affiliation":[{"name":"Survey Research Center, Institute for Social Research University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.S.","family":"Meier","sequence":"additional","affiliation":[{"name":"Michigan Center on the Demography of Aging (MiCDA)  Ann Arbor MI USA"},{"name":"Survey Research Center, Institute for Social Research University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Brahmsteadt","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Faul","sequence":"additional","affiliation":[{"name":"Michigan Center on the Demography of Aging (MiCDA)  Ann Arbor MI USA"},{"name":"Survey Research Center, Institute for Social Research University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-015-0463-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy067"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-017-0951-y"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Muscle weakness and functional limitations in an ethnically diverse sample of older adults","volume":"26","author":"McGrath RP","year":"2017","journal-title":"Ethn Health"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111462"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.240"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.8.859"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.18314"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw051"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.03.011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01871"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.01.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62349-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw096"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264316656517"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.062"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1119-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12421"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.23285"},{"key":"e_1_2_8_24_1","unstructured":"Bureau UC.An aging nation: the older population in the United States.2014:25\u20101140. 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