{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:45Z","timestamp":1790187165152,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020448","name":"Korean Society for the Study of Obesity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is lack of data on effect modification by age on the association between body mass index (BMI) or waist circumference (WC) and cardiovascular diseases (CVDs). We aimed to investigate the impact of BMI and WC on incident CVDs in individuals aged 40 and 66\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 2\u00a0430\u00a0510 participants who underwent a national health screening for transitional ages provided by the Korean National Health Insurance Service between 2009 and 2012 were included. The adjusted hazard ratios and 95% confidence intervals for myocardial infarction (MI), ischaemic stroke and CVDs as a composite outcome of MI and ischaemic stroke were calculated using multivariable Cox proportional hazard regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow\u2010up of 7.7\u00a0years, 24\u00a0884 MI and 29\u00a0415 ischaemic stroke events occurred. Among participants aged 40\u00a0years, there was a J\u2010shaped association of BMI with incident CVDs, MI and ischaemic stroke with nadir at BMI 18.5\u201322.9\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic> for trend\u00a0&lt; 0.001 for all). Among those aged 66\u00a0years, there were significant U\u2010shaped associations of BMI with CVDs and MI with nadir at a BMI of 23.0\u201324.9\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic> for trend 0.013 and 0.017, respectively). WC was linearly associated with all study outcomes in both age groups (<jats:italic>P<\/jats:italic> for trend\u00a0&lt;&amp;nbsp;0.001). The impact of general and abdominal obesity on both study outcomes was more prominent in those aged 40\u00a0years than in those aged 66\u00a0years (<jats:italic>P<\/jats:italic> for interaction\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To prevent cardiovascular risk, weight loss intervention should be cautiously implemented and individualized according to age. The maintenance of muscle mass may be essential in managing weight loss particularly in older population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13138","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T04:50:25Z","timestamp":1671166225000},"page":"369-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66\u00a0years)"],"prefix":"10.1002","volume":"14","author":[{"given":"Jung Eun","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Family Medicine Healthcare System Gangnam Center Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010Im","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, CHA Bundang Medical Center CHA University  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Won","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Jung","family":"Rhee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Eun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.326"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004042","article-title":"Age\u2010dependent decline of association between obesity and coronary heart disease: a cohort study in a remote Australian Aboriginal community","volume":"3","author":"Wang Z","year":"2013","journal-title":"BMJ 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