{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:21:18Z","timestamp":1784737278039,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010390","name":"Saint Louis University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006556","name":"Centre Hospitalier Universitaire de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late\u2010life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15 (GDF\u201015), a stress signalling protein involved in aging, exercise and appetite control, on the association between PA and late\u2010life\u2010associated weight loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One thousand eighty\u2010three healthy adults (63.8% women) aged 70\u00a0years and over who participated in the Multidomain Alzheimer Preventive Trial were included. Bodyweight (kg) and PA levels (square root of metabolic equivalent of task\u2010min\/week) were assessed repeatedly from baseline to the 3\u2010year visit, whereas plasma GDF\u201015 (pg\/mL) was measured at the 1\u2010year visit. Multiple linear regressions were performed to test the association between first\u2010year mean PA level, 1\u2010year visit GDF\u201015 concentration and subsequent bodyweight changes. Mediation analyses were used to investigate whether GDF\u201015 mediated the association between first\u2010year mean PA levels and consecutive bodyweight changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple regression analyses demonstrated that higher first\u2010year mean PA levels significantly predicted lower GDF\u201015 and bodyweight at 1\u00a0year (B\u00a0=\u00a0\u22122.22; SE\u00a0=\u00a00.79; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). In addition, higher 1\u2010year visit GDF\u201015 levels were associated with faster subsequent bodyweight loss (Time\u00a0\u00d7\u00a0GDF\u201015 interaction B\u00a0=\u00a0\u22120.0004; SE\u00a0=\u00a00.0001; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Mediation analyses confirmed that GDF\u201015 mediated the association between first\u2010year mean PA levels and subsequent bodyweight changes (mediated effect ab\u00a0=\u00a00.0018; bootstrap SE\u00a0=\u00a00.001; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and revealed that mean PA had no direct effect on subsequent bodyweight changes (c\u2032 =\u00a00.006; SE\u00a0=\u00a00.008; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that GDF\u201015 may be one of the molecules mediating the link between PA and late\u2010life weight loss, but mechanistic studies are necessary to further support the present findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13152","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T08:43:50Z","timestamp":1674204230000},"page":"771-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-9113","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Raffin","sequence":"first","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Parini","sequence":"additional","affiliation":[{"name":"Institute of Metabolic and Cardiovascular Diseases, UMR1048  Toulouse Cedex 4 France"},{"name":"Paul Sabatier University  Toulouse Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lucas","sequence":"additional","affiliation":[{"name":"Institute of Metabolic and Cardiovascular Diseases, UMR1048  Toulouse Cedex 4 France"},{"name":"Paul Sabatier University  Toulouse Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the MAPT\/DSA 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