{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:31:58Z","timestamp":1791045118603,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012515","name":"Cyrus Tang Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001547","name":"China Medical Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The associations between body flexibility and sarcopenia were not well understood. This study aimed to explore the cross\u2010sectional and longitudinal associations of flexibility with sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study selected participants aged 50\u201380 from the WELL\u2010China cohort and the Lanxi cohort. Participants from the urban area of the Lanxi cohort were followed up 4\u00a0years later. Body flexibility was measured by the sit\u2010and\u2010reach test. Muscle mass was evaluated by dual\u2010energy X\u2010ray absorptiometry. Muscle strength was evaluated using handgrip strength. Sarcopenia was defined as having both low muscle mass and low muscle strength. We used multivariable logistic regressions to assess the cross\u2010sectional associations of body flexibility with low muscle mass, low muscle strength and sarcopenia. We also used multivariable logistic regressions to explore the associations of baseline flexibility and 4\u2010year changes in flexibility with incident low muscle mass, low muscle strength and sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9453 participants were enrolled in the cross\u2010sectional study, and 1233 participants were included in the longitudinal analyses. In the cross\u2010sectional analyses, compared with low body flexibility, high body flexibility was inversely associated with low muscle mass (odds ratio [OR], 0.58; 95% confidence interval [CI], 0.50\u20130.68; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), low muscle strength (OR, 0.62; 95% CI, 0.55\u20130.69; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and sarcopenia (OR, 0.52; 95% CI, 0.41\u20130.65; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and these associations did not differ in different age groups, sex or physical activity levels. In the longitudinal analyses, compared with participants with low body flexibility, participants with high body flexibility had lower risk of the incident low muscle strength (OR, 0.53; 95% CI, 0.38\u20130.74; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and sarcopenia (OR, 0.36; 95% CI, 0.21\u20130.61; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not incident low muscle mass (OR, 0.59; 95% CI, 0.33\u20131.06; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.076). Every 1\u2010cm increase in flexibility during 4\u00a0years was associated with reduced risk of incident low muscle mass (OR, 0.96; 95% CI, 0.93\u20131.00; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025), low muscle strength (OR, 0.96; 95% CI, 0.94\u20130.98; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and sarcopenia (OR, 0.96; 95% CI, 0.93\u20130.99; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High flexibility was associated with reduced risk of incident low muscle strength and sarcopenia. Increases in flexibility were associated with reduced risk of incident low muscle mass, low muscle strength and sarcopenia. Flexibility exercises and monitoring the dynamic change of flexibility might be helpful in preventing sarcopenia among adults aged 50\u00a0years or over.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13157","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:22:15Z","timestamp":1671841335000},"page":"534-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cross\u2010sectional and longitudinal associations between body flexibility and sarcopenia"],"prefix":"10.1002","volume":"14","author":[{"given":"Peng","family":"Gao","sequence":"first","affiliation":[{"name":"Chronic Disease Research Institute, The Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine Zhejiang 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Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Chronic Disease Research Institute, The Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Wu","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine Stanford University  Stanford CA 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