{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:14:13Z","timestamp":1790111653243,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study aims to clarify the association of sarcopenia with perioperative and postoperative complications in oral cavity squamous cell carcinoma (OCSCC) patients undergoing curative surgery and to understand the reasons causing the poor oncologic outcomes for OCSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a propensity score matching study to investigate the association of perioperative and postoperative outcomes in OCSCC patients with sarcopenia and without sarcopenia. A retrospective analysis of a large national data set from the Taiwan Cancer Registry Database was conducted. At least two claims for patients with a principal diagnosis of sarcopenia within the 12\u2010month preoperative period were defined as the criteria for sarcopenia diagnosis (ICD\u201010\u2010CM code M62.84). Sarcopenia was diagnosed through the measurement of low muscle strength and low muscle mass by any one of the patient's attending orthopaedic physician, rehabilitation physician, family medicine specialist or geriatrician. A multivariate logistic regression model was used to calculate the perioperative, and postoperative major complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our final cohort included 16\u00a0293 patients with OCSCC (10\u00a0862 and 5\u00a0431 in the sarcopenia and nonsarcopenia groups, respectively) who were eligible for further analysis. The sarcopenia group was 10.40% female and 89.60% male, and the nonsarcopenia group was 9.74% female and 90.26% male. The mean age\u00a0\u00b1\u00a0standard deviation (<jats:italic>SD<\/jats:italic>) were 56.44\u00a0\u00b1\u00a011.14 and 56.22\u00a0\u00b1\u00a011.29 for sarcopenia and nonsarcopenia groups. OCSCC patients with sarcopenia undergoing curative surgery had a significantly higher blood transfusion rate and volume; longer intensive care unit (ICU) stay, and hospital stay; higher postoperative 30\u2010day mortality (adjusted odds ratio [aOR]: 1.12, 95% confidence interval [CI] [1.07, 1.56]) and rates of pneumonia (aOR: 1.34, 95% CI [1.20, 1.50]), acute renal failure (aOR: 1.45, 95% CI [1.12, 1.87]) and septicaemia (aOR: 1.29, 95% CI [1.15, 1.45]); higher postoperative first\u2010year mortality (aOR: 1.18, 95% CI [1.13, 1.51]) and rates of pneumonia (aOR: 1.43, 95% CI [1.30, 1.56]), acute myocardial infarction (aOR: 1.52, 95% CI [1.06, 2.18]) and septicaemia (aOR: 1.29, 95% CI [1.15, 1.45]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OCSCC patients with sarcopenia might exhibit more perioperative and surgical complications than those without sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13162","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T09:58:16Z","timestamp":1671789496000},"page":"576-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of surgical complications after curative surgery in patients with oral cavity squamous cell carcinoma and sarcopenia"],"prefix":"10.1002","volume":"14","author":[{"given":"Shuang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Academy of Medical Sciences of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Lo\u2010Hsu Medical Foundation, Lotung Poh\u2010Ai Hospital  Luodong Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management Fu Jen Catholic University  Taipei Taiwan"},{"name":"Artificial Intelligence Development Center Fu Jen Catholic University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu\u2010Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management Fu Jen Catholic University  Taipei Taiwan"},{"name":"Artificial Intelligence Development Center Fu Jen Catholic University  Taipei Taiwan"},{"name":"Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science Asia University  Taichung Taiwan"},{"name":"Big Data Center Lo\u2010Hsu Medical Foundation, Lotung Poh\u2010Ai Hospital  Luodong Yilan Taiwan"},{"name":"Division of Radiation Oncology Lo\u2010Hsu Medical Foundation, Lotung Poh\u2010Ai Hospital  Luodong Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Definitive intensity\u2010modulated radiotherapy or surgery for early oral cavity squamous 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