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Our study aimed to investigate the cross\u2010sectional and longitudinal associations between plasma inflammation\u2010related biomarkers and IC in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) included 1238 community\u2010dwelling older individuals with IC assessments from 12 to 60\u00a0months. Plasma C\u2010reactive protein (CRP), interleukin\u20106 (IL\u20106), tumour necrosis factor receptor\u20101 (TNFR\u20101), monocyte chemoattractant protein\u20101 (MCP\u20101) and growth differentiation factor\u201015 (GDF\u201015) were measured at 12\u00a0months. IC was operationalized as a score ranging from 0 to 100, derived from four domains: cognition, <jats:italic>Mini\u2010Mental State Examination<\/jats:italic>; locomotion, <jats:italic>Short Physical Performance Battery<\/jats:italic>; psychological, <jats:italic>Geriatric Depression Scale<\/jats:italic>; and vitality, <jats:italic>handgrip strength<\/jats:italic>. A five\u2010domain IC score (plus sensory) was investigated in a subsample (<jats:italic>n<\/jats:italic>\u00a0=\u00a0535) with a 1\u2010year follow\u2010up as an exploratory outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the 1238 participants was 76.2\u00a0years (SD\u00a0=\u00a04.3); 63.7% were female. Their initial four\u2010domain IC scores averaged 78.9 points (SD\u00a0=\u00a09.3), with a yearly decline of 1.17 points (95% CI\u00a0=\u00a0\u22121.30 to \u22121.05; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). We observed significant associations of lower baseline IC with higher CRP, IL\u20106, TNFR\u20101 and GDF\u201015, after controlling age, sex, MAPT group allocation and educational level [<jats:italic>CRP:<\/jats:italic> adjusted \u03b2 (95% CI)\u00a0=\u00a0\u22121.56 (\u22122.64 to \u22120.48); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005; <jats:italic>IL\u20106:<\/jats:italic> adjusted \u03b2\u00a0=\u00a0\u22123.16 (\u22124.82 to \u22121.50); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>TNFR\u20101:<\/jats:italic> adjusted \u03b2\u00a0=\u00a0\u22126.86 (\u221210.25 to \u22123.47); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>GDF\u201015:<\/jats:italic> adjusted \u03b2\u00a0=\u00a0\u22127.07 (\u221210.02 to \u22124.12); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. Higher TNFR\u20101, MCP\u20101 and GDF\u201015 were associated with faster decline in four\u2010domain IC over 4\u00a0years [<jats:italic>TNFR\u20101:<\/jats:italic> adjusted \u03b2 (95% CI)\u00a0=\u00a0\u22121.28 (\u22122.29 to \u22120.27); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013; <jats:italic>MCP\u20101:<\/jats:italic> adjusted \u03b2\u00a0=\u00a0\u22121.33 (\u22122.24 to \u22120.42); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004; <jats:italic>GDF\u201015:<\/jats:italic> adjusted \u03b2\u00a0=\u00a0\u22121.42 (\u22122.26 to \u22120.58); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001]. None of the biomarkers was significantly associated with the five\u2010domain IC decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inflammation was associated with lower IC in older adults. Among all plasma biomarkers, TNFR\u20101 and GDF\u201015 were consistently associated with IC at the cross\u2010sectional and longitudinal levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13163","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T08:42:18Z","timestamp":1674204138000},"page":"930-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Plasma inflammation\u2010related biomarkers are associated with intrinsic capacity in community\u2010dwelling older adults"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-4214","authenticated-orcid":false,"given":"Wan\u2010Hsuan","family":"Lu","sequence":"first","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"Maintain Aging Research Team, CERPOP, Inserm, Universit\u00e9 Paul Sabatier  Toulouse 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