{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:46:03Z","timestamp":1792017963620,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["3020220160"],"award-info":[{"award-number":["3020220160"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ageing traits and frailty are important health issues in modern medicine. Evidence supporting the causal effects of tobacco smoking on various ageing traits is required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study performed Mendelian randomization (MR) analysis instrumenting 377 genetic variants associated with being an ever\u2010smoker at a genome\u2010wide significance level to test the causal estimates from tobacco smoking. The outcome data were obtained from 337\u2009138 white British ancestry participants from the UK Biobank. Leucocyte telomere length, appendicular lean mass index, subjective walking pace, handgrip strength,\u00a0and wristband accelerometry\u2010determined physical activity degree were collected as ageing\u2010related outcomes. Summary\u2010level MR analysis was performed using the inverse variance\u2010weighted method and pleiotropy\u2010robust MR methods, including weighted median and MR\u2010Egger. Observational association between the outcome traits and phenotypically being an ever\u2010smoker was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Summary\u2010level MR analysis indicated that a higher genetic predisposition for tobacco smoking was significantly associated with shorter leucocyte telomere length (twofold increase in prevalence of smoking towards standardized Z\u2010score, \u22120.041 [\u22120.054, \u22120.028]), lower appendicular lean mass index (\u22120.007 [\u22120.010, \u22120.005]), slower walking pace (ordinal category, \u22120.047 [\u22120.054, \u22120.033]) and lower time spent on moderate\u2010to\u2010vigorous physical activity (hours per week, \u22120.39 [\u22120.56, \u22120.23]). The causal estimates were non\u2010significant towards handgrip strength phenotype (kg, 0.074 [\u22120.055, 0.204]). Pleiotropy\u2010robust MR results generally supported the main causal estimates. The observational findings also showed significant association between being an ever\u2010smoker and the ageing traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Genetically predicted and observational tobacco smoking status are significantly associated with poor ageing phenotypes. Healthcare providers may continue to reduce tobacco use, which may be helpful in reducing the burden of ageing and frailty.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13174","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:10:10Z","timestamp":1674691810000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia"],"prefix":"10.1002","volume":"14","author":[{"given":"Sehoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong 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