{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:14:29Z","timestamp":1788466469055,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8220120355"],"award-info":[{"award-number":["8220120355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201812097"],"award-info":[{"award-number":["SZSM201812097"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20200109140412476"],"award-info":[{"award-number":["JCYJ20200109140412476"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance imaging (MRI) is the gold standard for evaluating body composition. However, the reference ranges have not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three lean tissue and seven adipose tissue parameters based on MRI data from the UK Biobank were used in this study. Participants with European ancestry and data on at least one parameter were screened. Age\u2010 and sex\u2010specific percentile curves were generated using the lambda\u2013mu\u2013sigma method. Three levels of reference ranges were provided, which were equivalent to the mean\u00a0\u00b1\u00a01 standard deviation (<jats:italic>SD<\/jats:italic>), 2 <jats:italic>SD<\/jats:italic>s and 2.5 <jats:italic>SD<\/jats:italic>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final analysis set for each parameter ranged from 4842 to 14\u00a0148 participants (53.4%\u201356.6% women) with a median age of 61. For lean tissue parameters, compared with those at age 45, the median total lean tissue volume and total thigh fat\u2010free muscle volume at age 70 were 2.83 and 1.73\u00a0L, and 3.02 and 1.51\u00a0L lower in men and women, respectively. The median weight\u2010to\u2010muscle ratios at age 45 were 0.51 and 0.83\u00a0kg\/L lower compared with those at age 70 in men and women, respectively. Adipose tissue parameters showed inconsistent differences. In men, the median muscle fat infiltration, visceral adipose tissue (VAT) volume, total abdominal adipose tissue index and abdominal fat ratio were 1.48%, 0.32\u00a0L, 0.08\u00a0L\/m<jats:sup>2<\/jats:sup> and 0.4 higher, and the median abdominal subcutaneous adipose tissue (ASAT) volume and total adipose tissue volume were 0.47 and 0.41\u00a0L lower, respectively, at age 70 than at age 45. The median total trunk fat volume was approximately 9.53\u00a0L at all ages. In women, the median muscle fat infiltration and VAT volume were 1.68% and 0.76\u00a0L higher, respectively, at age 70 than at age 45. The median ASAT volume, total adipose tissue volume, total trunk fat volume, total abdominal adipose tissue index and abdominal fat ratio were 0.35\u00a0L, 0.78\u00a0L, 1.12\u00a0L, 0.49\u00a0L\/m<jats:sup>2<\/jats:sup> and 0.06 higher, respectively, at age 60 than at age 45. The medians of the former three parameters were 0.33\u00a0L, 0.14\u00a0L and 0.20\u00a0L lower, at age 70 than at age 60. The medians of the latter two parameters were approximately 3.64\u00a0L\/m<jats:sup>2<\/jats:sup> and 0.55 at ages between 60 and 70.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have established reference ranges for MRI\u2010measured body composition parameters in a large community\u2010dwelling population. These findings provide a more accurate assessment of abnormal adipose and muscle conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13181","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T03:39:00Z","timestamp":1675136340000},"page":"992-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Defining reference values for body composition indices by magnetic resonance imaging in UK Biobank"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-7189","authenticated-orcid":false,"given":"Liang","family":"Dai","sequence":"first","affiliation":[{"name":"Clinical Research Academy Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Research Academy Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"},{"name":"Renal Division Peking University Shenzhen Hospital, Peking University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010qi","family":"Lu","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010yang","family":"Liu","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"},{"name":"College of Life Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong\u2010ying","family":"Song","sequence":"additional","affiliation":[{"name":"Clinical Research Academy Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renal Division Peking University Shenzhen Hospital, Peking University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Research Academy Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"},{"name":"Renal Division Peking University Shenzhen Hospital, Peking University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renal Division Peking University Shenzhen Hospital, Peking University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shan","sequence":"additional","affiliation":[{"name":"Clinical Research Academy Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Shenzhen Hospital, Peking University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2575"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-88"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.3788"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.131"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.87"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv509"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.10.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.06.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.6.1106"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12268"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-017-3552-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0349-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-019-00815-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0049-x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.0479"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28360"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.49"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12712"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280220958438"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2018-000722"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22210"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163332"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24726"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_8_28_1","volume-title":"Healthy ageing profiles: guidance for producing local health profiles of older people","author":"Kanstr\u00f6m L","year":"2008"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0596-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174180"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12523"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3361"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321319"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00114"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.06.010"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-45"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-3-9"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080079"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.13181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:18:01Z","timestamp":1692677881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/jcsm.13181"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13181","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"2022-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}