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These negative effects on skeletal muscle continue for several months or years and are aggravated by short\u2010term and long\u2010term disuse. The dynamic balance between muscle protein synthesis and muscle protein breakdown (proteolysis) is regulated by complex signalling pathways that leads to an overall negative protein balance in skeletal muscle after a burn injury. Research concerning these molecular mechanisms is still scarce and inconclusive, understanding of which, if any, molecular mechanisms contribute to muscle wasting is of fundamental importance in designing of therapeutic interventions for burn patients as well. This review not only summarizes our present knowledge of the molecular mechanisms that underpin muscle protein balance but also summarizes the effects of exercise on muscle wasting post\u2010burn as promising strategy to counteract the detrimental effects on skeletal muscle. Future research focusing on the pathways causing post\u2010burn muscle wasting and the different effects of exercise on them is needed to confirm this hypothesis and to lay the foundation of therapeutic strategies.<\/jats:p>","DOI":"10.1002\/jcsm.13188","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T06:19:22Z","timestamp":1676009962000},"page":"758-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Molecular mechanisms of post\u2010burn muscle wasting and the therapeutic potential of physical exercise"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8523-0742","authenticated-orcid":false,"given":"Dorien","family":"Dombrecht","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences &amp; Physiotherapy, Research group MOVANT, Multidisciplinary Metabolic Research Unit (M2RUN) University of Antwerp  Antwerp 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