{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:13:11Z","timestamp":1792818791349,"version":"4.5.0"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polypharmacy in older adults is associated with multiple negative consequences that may affect muscular function, independently from the presence of medical conditions. The aim of this systematic review and meta\u2010analysis was to investigate the association of sarcopenia with polypharmacy and higher number of medications. A systematic literature search of observational studies using PubMed, Web of Science, Scopus and Cochrane Library databases was conducted from inception until June 2022. To determine if sarcopenia is associated with a higher risk of polypharmacy and increased number of medications, a meta\u2010analysis using a random\u2010effects model was used to calculate the pooled effects (CRD42022337539). Twenty\u2010nine studies were included in the systematic review and meta\u2010analysis. Sarcopenia was associated with a higher prevalence of polypharmacy (odds ratio [OR]: 1.65, 95% confidence interval [CI] [1.23, 2.20],\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a084%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) and higher number of medications (mean difference: 1.39, 95% CI [0.59, 2.19],\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a095%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) compared with individuals without sarcopenia. Using meta\u2010regression, a high variance was observed due to different populations (i.e., community\u2010dwelling, nursing home residents, inpatients, outpatients) for both outcomes of polypharmacy (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.338, SE\u00a0=\u00a00.1669, 95% CI [\u22120.67, \u22120.01],\n                    <jats:italic>z<\/jats:italic>\n                    \u00a0=\u00a0\u22122.03,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.04) and number of medications (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.589, SE\u00a0=\u00a00.2615, 95% CI [0.08, 1.10],\n                    <jats:italic>z<\/jats:italic>\n                    \u00a0=\u00a02.25,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02). This systematic review and meta\u2010analysis reported a significantly increased risk of polypharmacy and higher number of medications in people with sarcopenia compared with individuals without this condition. Future research should clarify whether the specificity and number of medications is a direct contributor in accelerating the progression of muscle wasting and dysfunction contributing to sarcopenia in older adults.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.13190","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T20:20:02Z","timestamp":1676319602000},"page":"671-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sarcopenia is associated with a greater risk of polypharmacy and number of medications: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Biology, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool 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Health, Epidemiology and Health Economics, WHO Collaborating Center for Public Health Aspects of Musculo\u2010Skeletal Health and Ageing University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Section of Geriatrics, Department of Internal Medicine and Paediatrics Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Geriatria, Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento, IRCCS INRCA  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-4473","authenticated-orcid":false,"given":"Konstantinos K.","family":"Triantafyllidis","sequence":"additional","affiliation":[{"name":"Society of Meta\u2010research and Biomedical Innovation  London UK"},{"name":"Department of 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