{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:03:07Z","timestamp":1788184987458,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073330"],"award-info":[{"award-number":["82073330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872469"],"award-info":[{"award-number":["81872469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.17108"],"award-info":[{"award-number":["320.6750.17108"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.19089"],"award-info":[{"award-number":["320.6750.19089"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT) is the standard of care for locoregionally advanced nasopharyngeal carcinoma (LA\u2010NPC). This intensive treatment regimen increases acute toxicities, which could negatively impact patients' nutritional status. We conducted this prospective, multicentre trial to investigate the effects of IC and CCRT on nutritional status in LA\u2010NPC patients, so as to provide evidence for further study of nutritional intervention, which was registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (NCT02575547).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with biopsy\u2010proven NPC and planned for IC\u00a0+\u00a0CCRT were recruited. IC entailed two cycles of 3\u2010weekly docetaxel 75\u00a0mg\/m<jats:sup>2<\/jats:sup> and cisplatin 75\u00a0mg\/m<jats:sup>2<\/jats:sup>; CCRT entailed two to three cycles of 3\u2010weekly cisplatin 100\u00a0mg\/m<jats:sup>2<\/jats:sup> depending on the duration of radiotherapy. Nutritional status and quality of life (QoL) were assessed pre\u2010IC, post\u2010cycles one and two of IC, W4 and W7 of CCRT. Primary endpoint was the cumulative proportion of \u2265 5.0% weight loss (WL<jats:sub>5.0<\/jats:sub>) by the end of treatment (W7\u2010CCRT). Secondary endpoints included body mass index, NRS2002 and PG\u2010SGA scores, QoL, hypoalbuminaemia, treatment compliance, acute and late toxicities\u00a0and survivals. The associations between primary and secondary endpoints were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventy\u2010one patients were enrolled. Median follow\u2010up was 67.4 (IQR: 64.1\u201371.2) months. 97.7% (167\/171) patients completed two cycles of IC, and 87.7% (150\/171) completed at least two cycles of concurrent chemotherapy; all, except one patient (0.6%), completed IMRT. WL was minimal during IC (median of 0.0%), but increased sharply at W4\u2010CCRT (median of 4.0% [IQR: 0.0\u20137.0%]) and peaked at W7\u2010CCRT (median of 8.5% [IQR: 4.1\u201311.7%]). 71.9% (123\/171) of patients recorded a WL<jats:sub>5.0<\/jats:sub> by W7\u2010CCRT, which was associated with a higher malnutrition risk (NRS2002\u00a0\u2265\u00a03 points: 87.7% [WL\u00a0\u2265\u00a05.0%] <jats:italic>vs<\/jats:italic> 58.7% [WL\u00a0&lt;\u00a05.0%], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and requirement of nutritional intervention (PG\u2010SGA\u00a0\u2265\u00a09 points: 82.0% [WL\u00a0\u2265\u00a05.0%] <jats:italic>vs<\/jats:italic> 66.7% [WL &lt;\u00a05.0%], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038). The median %WL at W7\u2010CCRT was higher in patients who suffered from \u2265 G2 mucositis (9.0% <jats:italic>vs<\/jats:italic> 6.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) and xerostomia (9.1% <jats:italic>vs<\/jats:italic> 6.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Besides, patients with cumulative WL<jats:sub>5.0<\/jats:sub> also reported a higher detriment on QoL at W7\u2010CCRT compared with patients without, with a difference of \u22128.3 points (95% CI [\u221215.1, \u22121.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed a high prevalence of WL among LA\u2010NPC patients who were treated with IC\u00a0+\u00a0CCRT, which peaked during CCRT, and had a detriment on patients' QoL. Our data support the need to monitor patient's nutritional status during the later phase of treatment with IC\u00a0+\u00a0CCRT and inform on nutritional intervention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13196","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:35:54Z","timestamp":1678077354000},"page":"815-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of induction chemotherapy on nutrition status in locally advanced nasopharyngeal carcinoma: a multicentre prospective study"],"prefix":"10.1002","volume":"14","author":[{"given":"Jingjing","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enya H.W.","family":"Ong","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai 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of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson L.F.","family":"Yit","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Clinical Nutrition Beijing Shijitan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Huey","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials &amp; Epidemiological Sciences National Cancer Center Singapore  Singapore"},{"name":"Oncology Academic Programme, Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiang","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Key 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