{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:55:28Z","timestamp":1789419328097,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["K2118501"],"award-info":[{"award-number":["K2118501"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although gastric cancer patients generally experience drastic weight decrease post\u2010gastrectomy, the impact of weight decrease on type 2 diabetes risk remains unclear. We investigated the type 2 diabetes risk after gastric cancer surgery according to postoperative weight decrease in gastric cancer survivors in South Korea, the country with the world's highest rate of gastric cancer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective nationwide cohort study included gastric cancer surgery recipients between 2004 and 2014 who survived for \u22655\u00a0years post\u2010surgery. We included patients without a history of diabetes at the time of surgery and those who had not received adjuvant chemotherapy before or after the surgery. Postoperative weight loss was defined as the per cent body weight loss at 3\u00a0years post\u2010surgery compared with the baseline. The type 2 diabetes risk was evaluated using Cox regression analyses for five groups of postoperative weight decrease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 5618 included gastric cancer surgery recipients (mean age, 55.7 [standard deviation, SD, 10.9] years; 21.9% female; mean body mass index, 23.7 [SD, 2.9] kg\/m<jats:sup>2<\/jats:sup>), 331 patients (5.9%) developed postoperative type 2 diabetes during follow\u2010up duration of 8.1\u00a0years (median; interquartile range, 4.8\u00a0years; maximum, 15.2\u00a0years). Compared with those who gained weight post\u2010surgery, patients with \u2265\u00a0\u221215% to &lt;\u00a0\u221210% of postoperative weight decrease (hazard ratio, 0.65; 95% confidence interval, 0.49\u20130.87; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) had the lowest type 2 diabetes risk. A non\u2010linear association occurred between postoperative weight decrease and the type 2 diabetes risk in gastrectomy recipients (Akaike's information criterion [AIC] for non\u2010linear model, 5423.52; AIC for linear model, 5425.61).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A U\u2010shaped non\u2010linear association occurred between the type 2 diabetes risk and postoperative weight decrease in gastric cancer survivors who underwent gastrectomy. The lowest type 2 diabetes risk occurred in patients with \u2265\u00a0\u221215% to &lt;\u00a0\u221210% of postoperative weight decrease at 3\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13206","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T05:24:51Z","timestamp":1677821091000},"page":"826-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between weight change after gastric cancer surgery and type 2 diabetes risk: A nationwide cohort study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-7403","authenticated-orcid":false,"given":"Yeongkeun","family":"Kwon","sequence":"first","affiliation":[{"name":"Division of Foregut Surgery Korea University College of Medicine  Seoul South Korea"},{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul South Korea"},{"name":"Gut &amp; Metabolism Laboratory Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Ha","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit Massachusetts General Hospital  Boston, MA United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohyang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Statistics Daegu University  Gyeongsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinseub","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Statistics Daegu University  Gyeongsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Hoo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Foregut Surgery Korea University College of Medicine  Seoul South Korea"},{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul South Korea"},{"name":"Gut &amp; Metabolism Laboratory Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"BK21 FOUR Community\u2010Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Foregut Surgery Korea University College of Medicine  Seoul South Korea"},{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul South Korea"},{"name":"Gut &amp; Metabolism Laboratory Korea University College of Medicine  Seoul South 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