{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:29:12Z","timestamp":1792517352320,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The decrease of physical abilities and functional decline that can be caused by musculoskeletal conditions such as sarcopenia, can lead to higher levels of dependency and disability. Therefore, it may influence patient reported outcome measures (PROM), such as the health\u2010related quality of life (HRQoL). The purpose of this systematic review and meta\u2010analysis is to provide a comprehensive overview of the relationship between sarcopenia and HRQoL. Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) were followed throughout the whole process of this work. A protocol was previously published on PROSPERO. The electronic databases MEDLINE, Scopus, Allied and Complementary Medicine (AMED), EMB Review \u2013 ACP Journal Club, EBM Review \u2010 Cochrane Central of Register of Controlled Trials and APA PsychInfo were searched until October 2022 for observational studies reporting a HRQoL assessment in both sarcopenic and non\u2010sarcopenic individuals. Study selection and data extraction were carried out by two independent researchers. Meta\u2010analysis was performed using a random effect model, reporting an overall standardized mean difference (SMD) and its 95% confidence interval (CI) between sarcopenic and non\u2010sarcopenic individuals. Study quality was measured using the Newcastle\u2010Ottawa Scale and the strength of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. The search strategy identified 3725 references from which 43 observational studies were eligible and included in this meta\u2010synthesis study. A significantly lower HRQoL was observed for sarcopenic individuals compared with non\u2010sarcopenic ones (SMD \u22120.76; 95% CI \u22120.95; \u22120.57). Significant heterogeneity was associated with the model (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a093%,\n                    <jats:italic>Q<\/jats:italic>\n                    test\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value &lt;0.01). Subgroup analysis showed a higher effect size when using the specific questionnaire SarQoL compared with generic questionnaires (SMD \u22121.09; 95% CI \u22121.44; \u22120.74 with the SarQoL versus \u22120.49; 95% CI \u22120.63; \u22120.36 with generic tools;\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value for interaction &lt;0.01). A greater difference of HRQoL between sarcopenic and non\u2010sarcopenic was found for individuals residing in care homes compared with community\u2010dwelling individuals (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value for interaction &lt;0.001). No differences were found between age groups, diagnostic techniques, and continents\/regions. The level of evidence was rated as moderate using the GRADE assessment. This systematic review and meta\u2010analysis combining 43 observational studies shows that HRQoL is significantly reduced in sarcopenic patients. The use of disease\u2010specific HRQoL instruments may better discriminate sarcopenic patients with respect to their quality of life.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.13243","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T06:35:34Z","timestamp":1683182134000},"page":"1228-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Sarcopenia and health\u2010related quality of life: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-5303","authenticated-orcid":false,"given":"Charlotte","family":"Beaudart","sequence":"first","affiliation":[{"name":"WHO Collaborating Center for Public Health Aspects of Musculo\u2010skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Demonceau","sequence":"additional","affiliation":[{"name":"WHO Collaborating Center for Public Health Aspects of Musculo\u2010skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Reginster","sequence":"additional","affiliation":[{"name":"WHO Collaborating Center for Public Health Aspects of Musculo\u2010skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9d\u00e9a","family":"Locquet","sequence":"additional","affiliation":[{"name":"WHO Collaborating Center for Public Health Aspects of Musculo\u2010skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cesari","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"},{"name":"Geriatric Unit IRCCS Istituti Clinici Scientifici Maugeri  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso J.","family":"Cruz Jentoft","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda Hospital Universitario Ram\u00f3n y Cajal (IRYCIS)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bruy\u00e8re","sequence":"additional","affiliation":[{"name":"WHO Collaborating Center for Public Health Aspects of Musculo\u2010skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics University of Li\u00e8ge  Li\u00e8ge 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