{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:39:00Z","timestamp":1776944340302,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maintaining the ability to perform self\u2010care is a critical goal in patients with cancer. We assessed whether the patient\u2010reported ability to walk 4\u00a0m and wash oneself predict survival in patients with pre\u2010terminal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective observational study on 169 consecutive hospitalized patients with cancer (52% female, 64\u00a0\u00b1\u00a012\u00a0years) and an estimated 1\u201312\u00a0months prognosis at an academic, inpatient palliative care unit. Patients answered functional questions for \u2018today\u2019, \u2018last week\u2019, and \u2018last month\u2019, performed patient\u2010reported outcomes (PROs), and physical function assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two (54%) patients reported the ability to independently walk 4\u00a0m and 100 (59%) to wash \u2018today\u2019. The median number of days patients reported the ability to walk 4\u00a0m and wash were 6 (IQR 0\u20137) and 7 (0\u20137) days (\u2018last week\u2019); and 27 (5\u201330) and 26 (10\u201330) days (\u2018last month\u2019). In the last week, 32% of patients were unable to walk 4\u00a0m on every day and 10% could walk on 1\u20133\u00a0days; 30% were unable to wash on every day and 10% could wash on 1\u20133\u00a0days. In the last months, 14% of patients were unable to walk 4\u00a0m on every day and 10% could only walk on 1\u201310\u00a0days; 12% were unable to wash on every day and 11% could wash on 1\u201310\u00a0days. In patients who could walk \u2018today\u2019 average 4\u00a0m gait speed was 0.78\u00a0\u00b1\u00a00.28\u00a0m\/s. Patients who reported impaired walking and washing experienced more symptoms (dyspnoea, exertion, and oedema) and decreased physical function (higher Eastern Cooperative Oncology Group Performance Status, and lower Karnofsky Performance Status and hand\u2010grip strength [unable vs. able to walk \u2018today\u2019: 205\u00a0\u00b1\u00a087 vs. 252\u00a0\u00b1\u00a078 Newton, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001; unable vs. able to wash \u2018today\u2019: 204\u00a0\u00b1\u00a086 vs. 250\u00a0\u00b1\u00a080 Newton, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001]). During the 27\u00a0months of observation, 152 (90%) patients died (median survival 46\u00a0days). In multivariable Cox proportional hazards regression analyses, all tested parameters were independent predictors of survival: walking 4\u00a0m \u2018today\u2019 (HR 0.63, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015), \u2018last week\u2019 (per 1\u00a0day: HR 0.93, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), \u2018last month\u2019 (per 1\u00a0day: HR 0.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012), 4\u00a0m gait speed (per 1\u00a0m\/s: HR 0.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), and washing \u2018today\u2019 (HR 0.67, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.024), \u2018last week (per 1 day HR 0.94, p=0.019), and \u2018last month\u2019 (per 1\u00a0day HR 0.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.040). Patients unable to walk and wash experienced the shortest survival and most reduced functional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with pre\u2010terminal cancer, the self\u2010reported ability to walk 4\u00a0m and wash were independent predictors of survival and associated with decreased functional status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13247","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T07:46:44Z","timestamp":1684914404000},"page":"1670-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patient\u2010reported ability to walk 4\u00a0m and to wash: New clinical endpoints and predictors of survival in patients with pre\u2010terminal cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-8555","authenticated-orcid":false,"given":"Markus 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