{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:34:15Z","timestamp":1784327655995,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is known that S\u2010pindolol attenuates muscle loss in animal models of cancer cachexia and sarcopenia. In cancer cachexia, it also significantly reduced mortality and improved cardiac function, which is strongly compromised in cachectic animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we tested 3\u00a0mg\/kg\/day of S\u2010pindolol in two murine cancer cachexia models: pancreatic cancer cachexia (KPC) and Lewis lung carcinoma (LLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment of mice with 3\u00a0mg\/kg\/day of S\u2010pindolol in KPC or LLC cancer cachexia models significantly attenuated the loss of body weight, including lean mass and muscle weights, leading to improved grip strength compared with placebo\u2010treated mice. In the KPC model, treated mice lost less than half of the total weight lost by placebo (\u22120.9\u00a0\u00b1\u00a01.0 vs. \u22122.2\u00a0\u00b1\u00a01.4\u00a0g for S\u2010pindolol and placebo, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and around a third of the lean mass lost by tumour\u2010bearing controls (\u22120.4\u00a0\u00b1\u00a01.0 vs. \u22121.5\u00a0\u00b1\u00a01.5\u00a0g for S\u2010pindolol and placebo, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), whereas loss of fat mass was similar. In the LLC model, the gastrocnemius weight was higher in sham (108\u00a0\u00b1\u00a016\u00a0mg) and S\u2010pindolol tumour\u2010bearing (94\u00a0\u00b1\u00a015\u00a0mg) mice than that in placebo (83\u00a0\u00b1\u00a012\u00a0mg), whereas the soleus weight was only significantly higher in the S\u2010pindolol\u2010treated group (7.9\u00a0\u00b1\u00a01.7\u00a0mg) than that in placebo (6.5\u00a0\u00b1\u00a00.9). Grip strength was significantly improved by S\u2010pindolol treatment (110.8\u00a0\u00b1\u00a016.2 vs. 93.9\u00a0\u00b1\u00a017.1\u00a0g for S\u2010pindolol and placebo, respectively). A higher grip strength was observed in all groups; whereas S\u2010pindolol\u2010treated mice improved by 32.7\u00a0\u00b1\u00a018.5\u00a0g, tumour\u2010bearing mice only show minimal improvements (7.3\u00a0\u00b1\u00a019.4\u00a0g, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>S\u2010pindolol is an important candidate for clinical development in the treatment of cancer cachexia that strongly attenuates loss of body weight and lean body mass. This was also seen in the weight of individual muscles and resulted in higher grip strength.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13249","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:38:37Z","timestamp":1683070717000},"page":"1244-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of S\u2010pindolol in mouse pancreatic and lung cancer cachexia models"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-0117","authenticated-orcid":false,"given":"Jochen","family":"Springer","sequence":"first","affiliation":[{"name":"BIH Center for Regenerative Therapies Charit\u00e9 University Medical Center Berlin  Berlin Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queralt","family":"Jov\u00e9","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson Alves","family":"de Lima Junior","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia \u00c1lvarez","family":"Ladr\u00f3n","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"L\u00f3pez\u2010Soriano","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Busquets","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Argiles","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Marks","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12537"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0125-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0046-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12126"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12225"},{"key":"e_1_2_7_7_1","first-page":"939","article-title":"Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma","volume":"35","author":"Lippman MM","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20899"},{"key":"e_1_2_7_9_1","first-page":"189","article-title":"Cancer cachexia: physical activity and muscle force in tumour\u2010bearing rats","volume":"25","author":"Toledo M","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12778"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2022.11.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.054"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.5668"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T04:08:52Z","timestamp":1703822932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/jcsm.13249"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13249","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2023-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}