{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:34:52Z","timestamp":1792427692180,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012167","name":"National Science and Technology Infrastructure Program","doi-asserted-by":"publisher","award":["2015BAI12B06"],"award-info":[{"award-number":["2015BAI12B06"]}],"id":[{"id":"10.13039\/501100012167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170686"],"award-info":[{"award-number":["82170686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes. Few studies assess the correlation between frailty, sarcopenia and CKD in non\u2010dialysis patients. Therefore, this study aimed to determine frailty\u2010associated factors in elderly CKD stage I\u2013IV patients, expected to early identify and intervene in the frailty of elderly CKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 774 elderly CKD I\u2013IV patients (&gt;60\u00a0years of age) recruited from 29 clinical centers in China between March 2017 and September 2019 were included in this study. We established a Frailty Index (FI) model to evaluate frailty risk and verified the distributional property of FI in the study population. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia 2019. Multinomial logistic regression analysis was used to assess the associated factors for frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven hundred seventy\u2010four patients (median age 67\u00a0years, 66.0% males) were included in this analysis, with a median estimated glomerular filtration rate of 52.8\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      . The prevalence of sarcopenia was 30.6%. The FI exhibited a right\u2010skewed distribution. The age\u2010related slope of FI was 1.4% per year on a logarithmic scale (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.706, 95% CI 0.9, 1.8,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The upper limit of FI was around 0.43. The FI was related to mortality (HR\u00a0=\u00a01.06, 95% CI 1.00, 1.12,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.041). Multivariate multinomial logistic regression analysis showed that sarcopenia, advanced age, CKD stage II\u2013IV, low level of serum albumin and increased waist\u2013hip ratio were significantly associated with high FI status, while advanced age and CKD stage III\u2013IV were significantly associated with for median FI status. Moreover, the results from the subgroup were consistent with the leading results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia was independently associated with an increased risk for frailty in elderly CKD I\u2010IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist\u2013hip ratio and low serum albumin level should be assessed for frailty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13275","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T02:59:20Z","timestamp":1686365960000},"page":"1855-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Association between sarcopenia and frailty in elderly patients with chronic kidney disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-2236","authenticated-orcid":false,"given":"Che","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases  Beijing China"},{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases  Beijing China"},{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xieguanxuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases  Beijing 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