{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:38:25Z","timestamp":1792265905626,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007680","name":"Universidad P\u00fablica de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The World Health Organization proposed the concept of intrinsic capacity (IC; the composite of all the physical and mental capacities of the individual) as central for healthy ageing. However, little research has investigated the interaction and joint associations of IC with cardiovascular disease (CVD) incidence and CVD mortality in middle\u2010 and older\u2010aged adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from 443\u00a0130 UK Biobank participants, we analysed seven biomarkers capturing the level of functioning of five domains of IC to calculate a total IC score (ranging from 0 [better IC] to +4 points [poor IC]). Associations between IC score and incidence of six long\u2010term CVD conditions (hypertension, stroke\/transient ischaemic attack stroke, peripheral vascular disease, atrial fibrillation\/flutter, coronary artery disease and heart failure), and grouped mortality from these conditions were estimated using Cox proportional models, with a 1\u2010year landmark analysis to triangulate the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 10.6\u00a0years of follow\u2010up, CVD morbidity grouped (<jats:italic>n<\/jats:italic>\u00a0=\u00a0384\u00a0380 participants for the final analytic sample) was associated with IC scores (0 to +4): mean hazard ratio (HR) [95% confidence interval, CI] 1.11 [1.08\u20131.14], 1.20 [1.16\u20131.24], 1.29 [1.23\u20131.36] and 1.56 [1.45\u20131.59] in men (C\u2010index\u00a0=\u00a00.68), and 1.17 [1.13\u20131.20], 1.30 [1.26\u20131.36], 1.52 [1.45\u20131.59] and 1.78 [1.67\u20131.89] in women (C\u2010index\u00a0=\u00a00.70). In regard to mortality, our results indicated that the higher IC score (+4 points) was associated with a significant increase in subsequent CVD mortality (mean HR [95% CI]: 2.10 [1.81\u20132.43] in men [C\u2010index\u00a0=\u00a00.75] and 2.29 [1.85\u20132.84] in women [C\u2010index\u00a0=\u00a00.78]). Results of all sensitivity analyses by full sample, sex and age categories were largely consistent independent of major confounding factors (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IC deficit score is a powerful predictor of functional trajectories and vulnerabilities of the individual in relation to CVD incidence and premature death. Monitoring an individual's IC score may provide an early\u2010warning system to initiate preventive efforts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13283","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T06:17:18Z","timestamp":1689142638000},"page":"2054-2063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Association of intrinsic capacity with incidence and mortality of cardiovascular disease: Prospective study in UK Biobank"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-6960","authenticated-orcid":false,"given":"Robinson","family":"Ram\u00edrez\u2010V\u00e9lez","sequence":"first","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Iriarte\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-6250","authenticated-orcid":false,"given":"Guzman","family":"Santaf\u00e9","sequence":"additional","affiliation":[{"name":"Department of Statistics, Computer Science, and Mathematics Universidad P\u00fablica de Navarra (UPNA)  Pamplona Spain"},{"name":"InaMat Universidad P\u00fablica de Navarra (UPNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-9049","authenticated-orcid":false,"given":"Armando","family":"Malanda","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering Universidad P\u00fablica de Navarra (UPNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-0242","authenticated-orcid":false,"given":"John R.","family":"Beard","sequence":"additional","affiliation":[{"name":"Columbia Aging Center Columbia University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-7182","authenticated-orcid":false,"given":"Antonio","family":"Garcia\u2010Hermoso","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4272","authenticated-orcid":false,"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104654"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00516-4"},{"key":"e_1_2_9_4_1","volume-title":"Integrated Care for Older People (ICOPE): Guidance for Person\u2010Centred Assessment and Pathways in Primary Care","year":"2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512794"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60175-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001795"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1651"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62000-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026119"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab226"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz218"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-021-1702-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab279"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111926"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60404-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1555-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12373"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1503-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-021-1622-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0047279400020341"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980011000942"},{"key":"e_1_2_9_27_1","first-page":"116","article-title":"The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498\u00a0135 UK\u2010Biobank participants","volume":"38","author":"Celis\u2010Morales CA","year":"2017","journal-title":"Eur Heart J"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-020-00997-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60240-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30091-4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n604"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxt059"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.576079"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003097"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.851882"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2021.121"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T01:46:45Z","timestamp":1697161605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jcsm.13283"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13283","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"2023-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}