{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:54:35Z","timestamp":1782827675281,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309200"],"award-info":[{"award-number":["2017YFC1309200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The original weight loss grading system (WLGS) was developed in western population, which did not perform effectively in cancer patients from China. This study aimed to develop and validate the modified WLGS (mWLGS) in the prognostic assessment of cancer patients in China.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective multicentre real\u2010world cohort study involving 16\u00a0842 patients diagnosed with cancer was conducted. Cox regression was used to calculate the hazard ratios for overall survival. Logistic linear regression was used to assess the odds ratio for 90\u2010day outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>We calculated survival risks for the 25 mWLGS groups and clustered the approximate survival risks. Finally, we revised the prognostic grading system for mWLGS to include five grades of 0\u20134. Compared with the original WLGS, the mWLGS had a better prognostic differentiation effect in predicting the prognosis of patients with cancer. The survival rate gradually deteriorated with increasing grade of mWLGS, with the survival rate of grade 0 decreasing from 76.4% to 48.2% for grade 4 (76.4 vs. 72.8 vs. 66.1 vs. 57.0 vs. 48.2%, respectively). The mWLGS provides effective prognostic stratification for most site\u2010specific cancers, especially lung and gastrointestinal cancers. High\u2010grade mWLGS is independently associated with an increased risk of poor quality of life and adverse 90\u2010day outcomes. Multivariate Cox regression analysis showed that the mWLGS was an independent prognostic factor for cancer patients in the validation cohorts.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared with the original WLGS, the mWLGS can better stratify the prognosis of cancer patients. mWLGS is a useful tool for predicting survival, 90\u2010day outcomes, and quality of life in patients with cancer. These analyses may provide new insights into the application of WLGS in cancer patients in China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13287","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T08:44:56Z","timestamp":1689065096000},"page":"2090-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Development and applicability of modified weight loss grading system in cancer: a real\u2010world cohort study"],"prefix":"10.1002","volume":"14","author":[{"given":"Hailun","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotian","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"Beijing International Science and 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