{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:06:41Z","timestamp":1791932801911,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13GW0473A"],"award-info":[{"award-number":["13GW0473A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023530","name":"Forschungszentrum Dynamische Systeme, Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018854","name":"Sirtex Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parameters of body composition have prognostic potential in patients with oncologic diseases. The aim of the present study was to analyse the prognostic potential of radiomics\u2010based parameters of the skeletal musculature and adipose tissues in patients with advanced hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Radiomics features were extracted from a cohort of 297 HCC patients as post hoc sub\u2010study of the SORAMIC randomized controlled trial. Patients were treated with selective internal radiation therapy (SIRT) in combination with sorafenib or with sorafenib alone yielding two groups: (1) sorafenib monotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147) and (2) sorafenib and SIRT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0150). The main outcome was 1\u2010year survival. Segmentation of muscle tissue and adipose tissue was used to retrieve 881 features. Correlation analysis and feature cleansing yielded 292 features for each patient group and each tissue type. We combined 9 feature selection methods with 10 feature set compositions to build 90 feature sets. We used 11 classifiers to build 990 models. We subdivided the patient groups into a train and validation cohort and a test cohort, that is, one third of the patient groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We used the train and validation set to identify the best feature selection and classification model and applied it to the test set for each patient group. Classification yields for patients who underwent sorafenib monotherapy an accuracy of 75.51% and area under the curve (AUC) of 0.7576 (95% confidence interval [CI]: 0.6376\u20130.8776). For patients who underwent treatment with SIRT and sorafenib, results are accuracy\u00a0=\u00a078.00% and AUC\u00a0=\u00a00.8032 (95% CI: 0.6930\u20130.9134).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Parameters of radiomics\u2010based analysis of the skeletal musculature and adipose tissue predict 1\u2010year survival in patients with advanced HCC. The prognostic value of radiomics\u2010based parameters was higher in patients who were treated with SIRT and sorafenib.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13315","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:34:02Z","timestamp":1692632042000},"page":"2301-2309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Prognostic role of radiomics\u2010based body composition analysis for the 1\u2010year survival for hepatocellular carcinoma patients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-7917","authenticated-orcid":false,"given":"Sylvia","family":"Saalfeld","sequence":"first","affiliation":[{"name":"Research Campus STIMULATE at the University of Magdeburg  Magdeburg Germany"},{"name":"Department of Simulation and Graphics University of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kreher","sequence":"additional","affiliation":[{"name":"Research Campus STIMULATE at the University of Magdeburg  Magdeburg Germany"},{"name":"Department of Simulation and Graphics University of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Hille","sequence":"additional","affiliation":[{"name":"Research Campus STIMULATE at the University of Magdeburg  Magdeburg Germany"},{"name":"Department of Simulation and Graphics University of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Niemann","sequence":"additional","affiliation":[{"name":"University Library University of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattes","family":"Hinnerichs","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine OvGU Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"\u00d6cal","sequence":"additional","affiliation":[{"name":"Department of Radiology LMU University Hospital  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology Niels\u2010Stensen\u2010Kliniken Marienhospital  Osnabr\u00fcck Germany"},{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Zech","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Loewe","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular and Interventional Radiology, Department of Bioimaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"van Delden","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Academic University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vandecaveye","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Verslype","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sengel","sequence":"additional","affiliation":[{"name":"Department of Radiology Grenoble University Hospital  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bargellini","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Radiology Candiolo Cancer Institute  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Iezzi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radiologia d'Urgenza e Interventistica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Gastroenterologie, Sektion Hepatologie Universit\u00e4tsklinikum Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz J.","family":"Kl\u00fcmpen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Benckert","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Campus Virchow Klinikum, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin 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