{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:32Z","timestamp":1791475292758,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metabolic acidosis unfavourably influences the nutritional status of patients with non\u2010dialysis dependent chronic kidney disease (CKD) including the loss of muscle mass and functionality, but the benefits of correction are uncertain. We investigated the effects of correcting metabolic acidosis on nutritional status in patients with CKD in a systematic review and meta\u2010analysis. A search was conducted in MEDLINE and the Cochrane Library from inception to June 2023. Study selection, bias assessment, and data extraction were independently performed by two reviewers. The Cochrane risk of bias tool was used to assess the quality of individual studies. We applied random effects meta\u2010analysis to obtain pooled standardized mean difference (SMD) and 95% confidence intervals (CIs). We retrieved data from 12 intervention studies including 1995 patients, with a mean age of 63.7\u00a0\u00b1\u00a011.7\u00a0years, a mean estimated glomerular filtration rate of 29.8\u00a0\u00b1\u00a08.8\u00a0mL\/min per 1.73\u00a0m<jats:sup>2<\/jats:sup>, and 58% were male. Eleven studies performed an intervention with oral sodium bicarbonate compared with either placebo or with standard care and one study compared veverimer, an oral HCl\u2010binding polymer, with placebo. The mean change in serum bicarbonate was +3.6\u00a0mEq\/L in the intervention group and +0.4\u00a0mEq\/L in the control group. Correcting metabolic acidosis significantly improved muscle mass assessed by mid\u2010arm muscle circumference (SMD 0.35 [95% CI 0.16 to 0.54], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and functionality assessed with the sit\u2010to\u2010stand test (SMD \u22120.31 [95% CI \u22120.52 to 0.11], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). We found no statistically significant effects on dietary protein intake, handgrip strength, serum albumin and prealbumin concentrations, and blood urea nitrogen. Correcting metabolic acidosis in patients with CKD improves muscle mass and physical function. Correction of metabolic acidosis should be considered as part of the nutritional care for patients with CKD.<\/jats:p>","DOI":"10.1002\/jcsm.13330","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T09:19:52Z","timestamp":1695201592000},"page":"2498-2508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of correcting metabolic acidosis on muscle mass and functionality in chronic kidney disease: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-0303","authenticated-orcid":false,"given":"Wesley J.","family":"Visser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Dietetics, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma E.M.","family":"van de Braak","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen Centre for Food Sciences, Wageningen University  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke M.E.","family":"de Mik \u2010 van Egmond","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dietetics, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"van der Burgh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"de Roos","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen Centre for Food Sciences, Wageningen University  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"Jans","sequence":"additional","affiliation":[{"name":"Department of Dietetics Hospital Gelderse Vallei  Ede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"van der Hoef","sequence":"additional","affiliation":[{"name":"Department of Dietetics Hospital St. Antonius  Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne F.","family":"Olieman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dietetics, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout J.","family":"Hoorn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and 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