{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:55:42Z","timestamp":1784735742552,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2022822"],"award-info":[{"award-number":["BE2022822"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with decompensated cirrhosis (DC) are prone to skeletal muscle loss, namely, sarcopenia, before liver transplantation (LT). While sarcopenia is reportedly associated with adverse outcomes after LT, these findings are limited owing to mixed diseases and retrospective data. We investigated the association between sarcopenia and 1\u2010year overall survival (OS) in patients with DC after LT and established and validated a prediction model for postoperative OS based on sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 222 consecutive patients who underwent LT at our centre were registered between September 2020 and June 2022. Third lumbar spine skeletal muscle mass index was measured using computed tomography. Patients were divided into sarcopenia and non\u2010sarcopenia groups according to the skeletal muscle mass index, and baseline data and postoperative outcomes were collected, compared and analysed. The primary outcome was the 1\u2010year OS after LT. We established a dynamic nomogram of the OS predictive model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 177\u00a0DC patients [mean (standard deviation) age, 50.2\u00a0\u00b1\u00a09.3\u00a0years; 52 women (29.4%)]; 73 (41.2%) had sarcopenia. The mean (standard deviation) body mass index was 22.6\u00a0\u00b1\u00a04.5\u00a0kg\/m<jats:sup>2<\/jats:sup>, 28 (15.8%) patients had weight loss \u22655% within 6\u00a0months before admission, and the mean (standard deviation) model for end\u2010stage liver disease (MELD) score was 18.4\u00a0\u00b1\u00a07.9. Patients with sarcopenia had a longer duration of intensive care unit stay (4.1\u00a0\u00b1\u00a02.2 vs. 3.1\u00a0\u00b1\u00a01.1\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), higher rate of major complications (45.2% vs. 22.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and higher postoperative mortality (15.1% vs. 2.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) than those without sarcopenia. The median 1\u2010year OS after surgery was shorter in patients with sarcopenia than in those without (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Sarcopenia [hazard ratio (HR), 2.54; 95% confidence interval (CI), 1.54\u20135.63; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022], weight loss \u22655% (HR, 2.46; 95% CI, 1.39\u20135.09; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and MELD score (HR, 1.05; 95% CI, 1.01\u20131.09; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) were independent risk factors associated with 1\u2010year OS. The area under the curve of the established dynamic nomogram was 0.774, the calibration curve showed good consistency, and analysis of the decision curve showed more clinical benefits than the MELD score alone. High\u2010risk patients (&gt;102.9 points calculated using the nomogram) had a significantly reduced survival rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia is associated with adverse outcomes after LT in patients with DC. High\u2010risk patients should be classified by dynamic nomogram upon admission.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13334","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T05:31:20Z","timestamp":1695360680000},"page":"2602-2612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impact of sarcopenia on the survival of patients undergoing liver transplantation for decompensated liver cirrhosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-5952","authenticated-orcid":false,"given":"Da","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26972"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.040"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30828"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12774"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.774044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25346"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002741"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12095"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15122778"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.05.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.04.040"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31558"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0713"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002291"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.07.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2019.12.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32049"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24750"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24671"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30686"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.12.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12093"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002759"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15161"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12524"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15026"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1946"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30091-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12762"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.050"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20721"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20169"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13717"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:05:47Z","timestamp":1704949547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jcsm.13334"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13334","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"2023-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}