{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:34:32Z","timestamp":1792100072167,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the prognostic significance of body mass index in small\u2010cell lung cancer and explored whether skeletal muscle status affects the body mass index\u2013survival relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study evaluated data from patients who underwent platinum\u2010etoposide chemotherapy for small\u2010cell lung cancer between March 2010 and December 2021. Skeletal muscle status was assessed using non\u2010contrast computed tomography images of baseline positron\u2010emission tomography\u2010computed tomography, with the skeletal muscle index defined as the cross\u2010sectional area of skeletal muscle divided by height squared, and the average attenuation values of skeletal muscle. Cox proportional hazards regression analysis was used to determine the correlations of body mass index, skeletal muscle metrics, and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed the data of 1146 Asian patients (1006 men and 140 women, with a median age of 67\u00a0years [interquartile range: 61\u201372\u00a0years]), including 507 and 639 patients with limited and extensive disease, respectively. Being underweight, defined as a body mass index &lt;18.5\u00a0kg\/m<jats:sup>2<\/jats:sup>, was associated with shorter overall survival, independent of clinical covariates in both the limited\u2010disease (hazard ratio, 1.77; 95% confidence interval, 1.01\u20133.09) and extensive\u2010disease (hazard ratio, 1.71; 95% confidence interval, 1.18\u20132.48) groups. The prognostic value of being underweight remained significant after additional adjustment for skeletal muscle index and attenuation in both limited\u2010disease (hazard ratio, 1.96; 95% confidence interval, 1.09\u20133.51) and extensive\u2010disease (hazard ratio, 1.75; 95% confidence interval, 1.17\u20132.61) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Being underweight is an independent poor prognostic factor for shorter overall survival in Asian patients with small\u2010cell lung cancer, regardless of skeletal muscle status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13345","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:48:17Z","timestamp":1700678897000},"page":"2939-2947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic significance of body mass index in small\u2010cell lung cancer: Exploring the relationship with skeletal muscle status"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5464-2967","authenticated-orcid":false,"given":"Yong Jae","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-5344","authenticated-orcid":false,"given":"Young Cheol","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-9542","authenticated-orcid":false,"given":"Hyun Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-8081","authenticated-orcid":false,"given":"Min Jae","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chung\u2010Ang University Hospital Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-461X","authenticated-orcid":false,"given":"Sehhoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\u2010Oncology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-5436","authenticated-orcid":false,"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","volume-title":"Cancer Facts & Figures 2023","author":"American Cancer Society","year":"2023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30318-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.11.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.05.031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3043"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.07.022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NT.0000000000000092"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0137"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2997-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000690"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.801"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13174"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.4830"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12956"},{"key":"e_1_2_8_19_1","volume-title":"Regional Office for the Western Pacific. The Asia\u2010Pacific perspective: redefining obesity and its treatment","author":"World Health Organization","year":"2000"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.346140178"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00561-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24314"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0732"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70141-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021210576"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.035"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab148"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00963"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx286"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007721"},{"key":"e_1_2_8_35_1","first-page":"817","article-title":"Systematic review of prognostic roles of body mass index for patients undergoing lung cancer surgery: does the \u2018obesity paradox\u2019 really exist?","volume":"51","author":"Li S","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31829cf942"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.5241"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12950"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2022.2159045"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.1894"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:07:46Z","timestamp":1704949666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jcsm.13345"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13345","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}