{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:32:31Z","timestamp":1790616751252,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examined the incidence and predictors of clinical outcomes in metabolic dysfunction\u2010associated fatty liver disease (MAFLD), focusing on anthropometric parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with MAFLD were identified in nationwide databases and a hospital cohort. Primary endpoints were atherosclerotic cardiovascular disease (ASCVD) and advanced fibrosis. Logistic and Cox regression analyses were used to analyse the association between anthropometric parameters and endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 4407 of 15\u00a0256 (28.9%) and 6274 of 25\u00a0784 subjects (24.3%) had MAFLD in the nationwide database; of these, 403 (9.2%) and 437 (7.0%) subjects were of lean\/normal weight, respectively. Compared to the overweight\/obese group, the lean\/normal weight group had a significantly lower muscle mass (15.0 vs. 18.9\u00a0kg) and handgrip strength (31.9 vs. 35.1\u00a0kg) and had a higher ASCVD risk (9.0% vs. 6.3% and 15.9% vs. 8.5%;\n                      <jats:italic>P<\/jats:italic>\n                      s\u00a0&lt;\u00a00.001). Sarcopenia (odds ratio [OR], 6.66; 95% confidence interval [CI], 1.79\u201324.80) and handgrip strength (OR, 0.92; 95% CI, 0.86\u20130.97;\n                      <jats:italic>P<\/jats:italic>\n                      s\u00a0=\u00a00.005) were associated with the ASCVD risk in the lean\/normal weight group. In a hospital cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01363), the ASCVD risk was significantly higher in the lean\/normal weight group than in the overweight\/obese group (median follow\u2010up, 39.1\u00a0months). Muscle mass was inversely correlated with the ASCVD risk (hazard ratio [HR], 0.72; 95% CI, 0.56\u20130.94), while visceral adiposity was associated with advanced fibrosis (HR, 1.36; 95% CI, 1.10\u20131.69;\n                      <jats:italic>P<\/jats:italic>\n                      s\u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Muscle mass\/strength was significantly associated with the ASCVD risk in patients with MAFLD. Visceral adiposity was an independent predictor of advanced fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13351","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T01:30:28Z","timestamp":1698283828000},"page":"2747-2756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of anthropometric parameters on outcomes in Asians with metabolic dysfunction\u2010associated fatty liver disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Kyu Yeon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center CHA University  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center CHA University  Seongnam South 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Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine  Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-3688","authenticated-orcid":false,"given":"Yeonjung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center CHA University  Seongnam South 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