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Handgrip strength was assessed by dynamometer. Walking pace was self\u2010reported as slow, average or brisk. The study outcome was incident PD, determined by self\u2010report data, hospital admission records or death records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean handgrip strength was 23.5 (SD, 6.3) and 39.6 (SD, 8.9) kg for females and males, respectively. A total of 33\u00a0645 (8.0%), 221\u00a0682 (52.8%) and 164\u00a0245 (39.2%) participants reported slow, average and brisk walking pace, respectively. Over a median follow\u2010up duration of 12.5\u00a0years, 2152 participants developed incident PD. When handgrip strength was assessed as sex\u2010specific tertiles, compared with those in the third tertile, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of incident PD for participants in the second and first tertiles were 1.23 (1.09\u20131.39) and 1.60 (1.42\u20131.79), respectively. Compared with brisk walking pace, average (HR, 1.33; 95% CI: 1.20\u20131.47) or slow (HR, 1.84; 95% CI: 1.57\u20132.15) walking pace was associated with a higher risk of incident PD. A lower grip strength (Tertiles 1 and 2) and an average\/slow walking pace accounted for 23.8% and 19.9% of PD cases, respectively. When handgrip strength and walking pace were considered together, the highest risk of incident PD was observed in participants with both lowest handgrip strength and slow walking pace (HR, 2.89; 95% CI: 2.30\u20133.64). Genetic risks of PD did not significantly modify the relation of handgrip strength (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u00a0=\u00a00.371) or walking pace (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u00a0=\u00a00.082) with new\u2010onset PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low handgrip strength and slow walking pace were significantly associated with a higher risk of incident PD, regardless of the individuals' genetic risk profile.<\/jats:p>\n                  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