{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:48:11Z","timestamp":1781070491926,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Although many studies have investigated the association between body composition, cancer risk and mortality, predicting these risks through a single body composition measurement undoubtedly increases the limitations of the study. Few studies have explored the association between the trajectory of changes in body composition and the risk of cancer and death. We aimed to explore the association of predicted lean mass trajectories with cancer risk, cancer\u2010specific mortality and all\u2010cause mortality.<\/jats:p><\/jats:sec>Methods<\/jats:title>The participants in this study were all from the Kailuan cohort, a prospective, periodic, resurvey cohort study initiated in 2006. Latent mixture modelling was used to identify predicted lean mass trajectories for 2006\u20132010. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of the Cox proportional hazard models were used to describe the association between predicted lean mass trajectories and cancer risk and cancer\u2010specific and all\u2010cause mortality during follow\u2010up (2010\u20132021).<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 44\u00a0374 participants (average age, 53.01\u00a0\u00b1\u00a011.41\u00a0years, 78.99% men and 21.01% women) were enrolled in this study. Five distinct trajectories were identified: low\u2010stable (n<\/jats:italic>\u00a0=\u00a012\u00a0060), low\u2010increasing (n<\/jats:italic>\u00a0=\u00a08027), moderately stable\u2010decreasing (n<\/jats:italic>\u00a0=\u00a04725), moderately stable\u2010increasing (n\u00a0=\u00a08053) and high\u2010stable (n<\/jats:italic>\u00a0=\u00a011\u00a0509). During the 11\u2010year follow\u2010up period, 2183 cancer events were recorded. After adjusting for age, predicted fat mass in 2010, sex, BMI, sedentary, physical activity, smoke, alcohol use, salt consumption, high\u2010fat diet, high\u2010sensitivity C\u2010reactive protein, serum creatinine, family history of tumour, hypertension, diabetes mellitus, compared with the low\u2010stable group, participants in the low\u2010increasing group (HR\u00a0=\u00a00.851, 95% CI, 0.748\u20130.969), moderately stable\u2010increasing group (HR\u00a0=\u00a00.803, 95% CI, 0.697\u20130.925) and high\u2010stable group (HR\u00a0=\u00a00.770, 95% CI, 0.659\u20130.901) had a lower cancer risk, but not in the moderately stable\u2010decreasing group (HR\u00a0=\u00a00.864, 95% CI, 0.735\u20131.015). Compared with the low\u2010stable group, the risk of cancer\u2010specific mortality was reduced by 25.4% (8.8\u201338.9%), 36.5% (20.3\u201349.4%) and 35.4% (17.9\u201349.2%), and the risk of all\u2010cause mortality was reduced by 24.2% (16.9\u201330.8%), 37.0% (30.0\u201343.2%) and 47.4% (41.0\u201353.1%) in the low\u2010increasing, moderately stable\u2010increasing group and high\u2010stable groups, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Predicted lean mass trajectories may be closely associated with cancer risk and cancer\u2010specific and all\u2010cause mortality. Regular monitoring of body composition is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13370","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:49:45Z","timestamp":1700120985000},"page":"2916-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predicted lean body mass trajectories, and cancer risk and cancer\u2010specific and all\u2010cause mortality: A prospective cohort study"],"prefix":"10.1002","volume":"14","author":[{"given":"Chenan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Song","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotian","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 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Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation Beijing China"},{"name":"Beijing International Science and Technology 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of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:05:04Z","timestamp":1704949504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jcsm.13370"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13370","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"2023-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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