{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:02:33Z","timestamp":1789455753296,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little research has been undertaken on the benefits of frailty management within different hospital settings. The objective of this study is to provide evidence on the viability and effectiveness of frailty management in non\u2010geriatric hospital settings on mortality and functional decline after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the FRAILCLINIC (NCT02643069) study were used. FRAILCLINIC is a randomized controlled trial developed in non\u2010geriatric hospital inpatient settings (emergency room, cardiology and surgery) from Spain (2), Italy (2) and the United Kingdom (1). Inpatients must met frailty criteria (according to the Frailty Phenotype and\/or FRAIL scale), \u226575\u00a0years old. The control group (CG) received usual care. The intervention group (IG) received comprehensive geriatric assessment (CGA) and a coordinated intervention consisting in recommendations to the treating physician about polypharmacy, delirium, falls, nutrition and physical exercise plus a discharge plan. The main outcomes included functional decline (worsening \u22655 points in Barthel Index) and mortality at 3\u00a0months. We used multivariate logistic regression models adjusted by age, gender and the Charlson index. Intention\u2010to\u2010treat (ITT) and per\u2010protocol (PP) analyses were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight hundred twenty one participants (IG: 416; mean age 83.00\u00a0\u00b1\u00a04.91; 51.44% women; CG: 405; mean age 82.46\u00a0\u00b1\u00a06.03; 52.35% women) were included. In the IG, 77.16% of the participants followed the geriatric team's recommendations as implemented by the treating physicians. The intervention showed a benefit on functional decline and mortality [OR: 0.67(0.47\u20130.96),\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value 0.027 and 0.29(0.14\u20130.57),\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0&lt;\u00a00.001, respectively) when fully followed by the treating physician. A trend to benefit (close to statistical significance) in functional decline and mortality were also observed when any of the recommendations were not followed [OR (95% CI): 0.72 (0.51\u20131.01),\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value: 0.055; and 0.64 (0.37\u20131.10),\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value: 0.105, respectively].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An individualized intervention in frail in\u2010patients reduces the risk of functional deterioration and mortality at 3\u00a0months of follow\u2010up when a care management plan is designed and followed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13374","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T04:02:01Z","timestamp":1701144121000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of a randomized intervention by a geriatric team in frail hospital inpatients in non\u2010geriatric settings: FRAILCLINIC project"],"prefix":"10.1002","volume":"15","author":[{"given":"Marta","family":"Checa\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Servicio de Geriatr\u00eda Hospital Universitario de Getafe  Getafe Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Costa\u2010Grille","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda Hospital Universitario de Getafe  Getafe Spain"},{"name":"Fundaci\u00f3n para la Investigaci\u00f3n e Innovaci\u00f3n Biosanitaria de Atenci\u00f3n Primaria 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UK"},{"name":"School of Life and Health Sciences Aston University  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Scuteri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Landi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University of the Sacred Heart School of Medicine  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Solano\u2010Jaurrieta","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) and Geriatric Service, Monte Naranco Hospital  Oviedo 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