{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:53:16Z","timestamp":1794466396903,"version":"4.9.1"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Osteosarcopenia is defined as the concurrent occurrence of osteopenia\/osteoporosis and sarcopenia. The aim of the current study was to perform a systematic review with meta\u2010analysis to determine the global prevalence, risk factors and clinical outcomes of osteosarcopenia. This review was registered in PROSPERO (CRD42022351229). PubMed, Cochrane, Medline and Embase were searched from inception to February 2023 to retrieve eligible observational population\u2010based studies. Pooled osteosarcopenia prevalence was calculated with 95% confidence interval (CI), and subgroup analyses were performed. The risk factor of osteosarcopenia and its association with clinical outcomes were expressed as odds ratio (OR) and hazard ratio (HR), respectively. Heterogeneity was estimated using the\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    test. Study quality was assessed using validated instruments matched to study designs. The search identified 55\u00a0158 studies, and 66 studies (64\u00a0404 participants, mean age from 46.6 to 93\u00a0years) were analysed in the final analysis, including 48 cross\u2010sectional studies, 17 cohort studies and 1 case\u2013control study. Overall, the pooled prevalence of osteosarcopenia was 18.5% (95% CI: 16.7\u201320.3,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a098.7%), including 15.3% (95% CI: 13.2\u201317.4,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a097.6%) in men and 19.4% (95% CI: 16.9\u201321.9,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a098.5%) in women. The prevalence of osteosarcopenia diagnosed using sarcopenia plus osteopenia\/osteoporosis was 20.7% (95% CI: 17.1\u201324.4,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a098.55%), and the prevalence of using sarcopenia plus osteoporosis was 16.1% (95% CI: 13.3\u201318.9,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a098.0%). The global osteosarcopenia prevalence varied in different regions with 22.9% in Oceania, 21.6% in Asia, 20.8% in South America, 15.7% in North America and 10.9% in Europe. A statistically significant difference was found in the subgroups of the study population between the hospital (24.7%) and community (12.9%) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.001). Frailty (OR\u00a0=\u00a04.72, 95% CI: 2.71\u20138.23,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a061.1%), malnutrition (OR\u00a0=\u00a02.35, 95% CI: 1.62\u20133.40,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a050.0%), female sex (OR\u00a0=\u00a05.07, 95% CI: 2.96\u20138.69,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a073.0%) and higher age (OR\u00a0=\u00a01.10, 95% CI: 1.06\u20131.15,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    ==86.0%) were significantly associated with a higher risk for osteosarcopenia. Meta\u2010analysis of cohort studies showed that osteosarcopenia significantly increased the risk of fall (HR\u00a0=\u00a01.54, 95% CI: 1.20\u20131.97;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a01.0%, three studies), fracture (HR\u00a0=\u00a02.13, 95% CI: 1.61\u20132.81;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a067.8%, seven studies) and mortality (HR\u00a0=\u00a01.75, 95% CI: 1.34\u20132.28;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.0%, five studies). Despite the heterogeneity arising from varied definitions and criteria, our findings highlight a significant global prevalence of osteosarcopenia and its negative impact on clinical health. Standardizing diagnostic criteria for osteosarcopenia would be advantageous in the future, and early detection and management should be emphasized in this patient population.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.13392","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T22:58:41Z","timestamp":1702421921000},"page":"8-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Global epidemiological features and impact of osteosarcopenia: A comprehensive meta\u2010analysis and systematic review"],"prefix":"10.1002","volume":"15","author":[{"given":"Shanping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gerontology and Geriatric Chengdu Fifth People\u2019s Hospital  Chengdu China"},{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jinggangshan University, Center for Clinical Medicine Research of Jinggangshan University  Ji'an China"},{"name":"Department of Medicine Jinggangshan University  Ji'an China"},{"name":"Online Collaborative Research Center for Evidence\u2010Based Medicine Ministry of Education, Jinggangshan University Branch  Ji'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huping","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Nursing Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jinggangshan University, Center for Clinical Medicine Research of Jinggangshan University  Ji'an China"},{"name":"Department of Medicine Jinggangshan University  Ji'an China"},{"name":"Online Collaborative Research Center for Evidence\u2010Based Medicine Ministry of Education, Jinggangshan University Branch  Ji'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatric Chengdu Fifth People\u2019s Hospital  Chengdu China"},{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatric Chengdu Fifth People\u2019s Hospital  Chengdu China"},{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatric Chengdu Fifth People\u2019s Hospital  Chengdu China"},{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatric Chengdu Fifth People\u2019s Hospital  Chengdu China"},{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jinggangshan University, Center for Clinical Medicine Research of Jinggangshan University  Ji'an China"},{"name":"Department of Medicine Jinggangshan University  Ji'an China"},{"name":"Online Collaborative Research Center for Evidence\u2010Based Medicine Ministry of Education, Jinggangshan University Branch  Ji'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zou","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Affiliated Fifth People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Geriatric Diseases Institute of Chengdu  Chengdu China"},{"name":"Department of General Practice Chengdu Fifth People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-8517","authenticated-orcid":false,"given":"Pan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Nursing Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12567"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa755"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2020.05.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-01048-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.02.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2021.1951204"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105591"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4151-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05963-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13605"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.09.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e27"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/482940","article-title":"Sarco\u2010osteoporosis: prevalence and association with frailty in chinese community\u2010dwelling older adults","volume":"2015","author":"Wang YJ","year":"2015","journal-title":"Int J Endocrinol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.04.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00646-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4384-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124291"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12411"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30702"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.02.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4604"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12870"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2018.25.1.59"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3416"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237454"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082381"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-021-01968-y"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2021.104530"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000087"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-022-01059-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2022.63.9.873"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05086-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061994"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.07.032"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15050"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly162"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2019.01.015"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2021.11.002"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151459320940568"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2018.25.4.227"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02772-0"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-017-0302-x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12080"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-018-0079-6"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2016.10.013"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-018-0931-z"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"e_1_2_9_52_1","first-page":"109","article-title":"Benefits of estrogen replacement for skeletal muscle mass and function in post\u2010menopausal females: evidence from human and animal studies","volume":"43","author":"Tiidus PM","year":"2011","journal-title":"Eur J Med"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-00753-w"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt052"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21013"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.10.017"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1684\/pnv.2011.0310"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2378-6"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.26.15364"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.145110"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00445"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097608"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.22.07215-X"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050791"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12177"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517099"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T21:27:47Z","timestamp":1706822867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jcsm.13392"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13392","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"2023-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}