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This study aimed to evaluate the effect of baseline ferrokinetics on peak oxygen consumption (peakVO<jats:sub>2<\/jats:sub>) improvement after a 12\u2010week physical therapy programme in patients with stable HFpEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a post\u2010hoc sub\u2010analysis of a randomized clinical trial in which 59 stable patients with HFpEF were randomized to receive a 12\u2010week programme of inspiratory muscle training (IMT), functional electrical stimulation (FES), IMT\u00a0+\u00a0FES or usual care (UC) to evaluate change in peakVO<jats:sub>2<\/jats:sub> (NCT02638961). Serum ferritin and transferrin saturation (TSAT) determinations were assessed at baseline. ID was defined as ferritin &lt;100\u00a0ng\/mL and\/or TSAT &lt;20% if ferritin was within 100\u2013299\u00a0ng\/mL. We used a linear mixed regression model to analyse between\u2010treatment changes in peakVO<jats:sub>2<\/jats:sub> across ferrokinetics status at 12 and 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 74\u00a0\u00b1\u00a09\u00a0years, and 36 (61%) had ID. The mean of peakVO<jats:sub>2<\/jats:sub> was 9.9\u00a0\u00b1\u00a02.5\u00a0mL\/kg\/min. The median of ferritin and transferrin saturation (TSAT) was 91 (50\u2013181) ng\/mL and 23% (16\u201330), respectively. A total of 52 patients completed the trial (13 patients per arm). Compared with those patients on UC, patients allocated to any of the active arms showed less improvement in peak VO<jats:sub>2<\/jats:sub> when they showed ID (<jats:italic>P<\/jats:italic>\u2010value for interaction &lt;0.001), lower values of ferritin (<jats:italic>P<\/jats:italic>\u2010value for interaction &lt;0.001), or TSAT (<jats:italic>P<\/jats:italic>\u2010value for interaction &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ferrokinetics status plays an essential role in modifying the aerobic capacity response to physical therapies in patients with HFpEF. Further studies are required to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13419","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:00:05Z","timestamp":1705377605000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING\u2010HF trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Patricia","family":"Palau","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Department of Physiotherapy Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Universitat Jaume I  Castell\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"de La Espriella","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Campuzano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Fundaci\u00f3n de Alcorc\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"CIBER Cardiovascular  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Fern\u00e1ndez\u2010Cisnal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"CIBER Cardiovascular  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario, INCLIVA. 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