{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:43:11Z","timestamp":1793122991923,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Excess muscle fat is observed in obesity and associated with greater burden of cardiovascular risk factors and higher risk of mortality. Liraglutide reduces total body weight and visceral fat but its effect on muscle fat and adverse muscle composition is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a pre\u2010specified secondary analysis of a randomized, double\u2010blind, placebo\u2010controlled trial that examined the effects of liraglutide plus a lifestyle intervention on visceral adipose tissue and ectopic fat among adults without diabetes with body mass index \u226530\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or \u226527\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and metabolic syndrome. Participants were randomly assigned to a once\u2010daily subcutaneous injection of liraglutide (target dose 3.0\u00a0mg) or matching placebo for 40\u00a0weeks. Body fat distribution and muscle composition was assessed by magnetic resonance imaging at baseline and 40\u2010week follow\u2010up. Muscle composition was described by the combination of thigh muscle fat and muscle volume. Treatment difference (95% confidence intervals [CI]) was calculated by least\u2010square means adjusted for baseline thigh muscle fat. The association between changes in thigh muscle fat and changes in body weight were assessed using Spearman correlation coefficients. The effect of liraglutide versus placebo on adverse muscle composition, denoted by high thigh muscle fat and low thigh muscle volume, was explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 128 participants with follow\u2010up imaging (92.2% women, 36.7% Black), median muscle fat at baseline was 7.8%. The mean percent change in thigh muscle fat over median follow\u2010up of 36\u00a0weeks was \u22122.87% among participants randomized to liraglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a073) and 0.05% in the placebo group (absolute change: \u22120.23% vs. 0.01%). The estimated treatment difference adjusted for baseline thigh muscle fat was \u22120.24% (95% CI, \u22120.41 to \u22120.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value 0.009). Longitudinal change in thigh muscle fat was significantly associated with change in body weight in the placebo group but not the liraglutide group. The proportion of participants with adverse muscle composition decreased from 11.0% to 8.2% over follow\u2010up with liraglutide, but there was no change with placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a cohort of predominantly women with overweight or obesity in the absence of diabetes, once\u2010daily subcutaneous liraglutide was associated with a reduction in thigh muscle fat and adverse muscle composition compared with placebo. The contribution of muscle fat improvement to the cardiometabolic benefits of liraglutide requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13445","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T01:39:07Z","timestamp":1712021947000},"page":"1072-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Ambarish","family":"Pandey","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kershaw V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Segar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Texas Heart Institute  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Ayers","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Linge","sequence":"additional","affiliation":[{"name":"AMRA Medical and Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof D.","family":"Leinhard","sequence":"additional","affiliation":[{"name":"AMRA Medical and Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK), Berlin Institute of Health Center for Regenerative Therapies (BCRT), and German Centre for Cardiovascular Research (DZHK) Partner Site Berlin Charit\u00e9 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Baylor Heart and Vascular Institute Baylor University Medical Center  Dallas TX USA"},{"name":"Department of Medicine University of Mississippi School of Medicine  Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag H.","family":"Joshi","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Neeland","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017\u20102018","author":"Hales CM","year":"2020","journal-title":"NCHS Data 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