{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:48:43Z","timestamp":1792493323827,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2021\u2010031146\u2010I"],"award-info":[{"award-number":["RYC2021\u2010031146\u2010I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An adequate magnesium intake might lower the risk of frailty through its role in muscle function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from 81\u00a0524 women aged \u226560\u00a0years participating in the Nurses' Health Study. Total magnesium intake was obtained from repeated food frequency questionnaires administered between 1984 and 2010 and self\u2010reported information on supplementation. Frailty was defined as having at least three of the following five FRAIL scale criteria: fatigue, low strength, reduced aerobic capacity, having \u22655 chronic illnesses and weight loss\u00a0\u2265\u00a05%. The occurrence of frailty was assessed every 4\u00a0years from 1992 to 2018. Cox proportional hazards models adjusted for lifestyle factors, medication use and dietary factors were used to assess the association between magnesium intake and frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 16\u00a0years, we identified 15\u00a0477 incident cases of frailty. Women with a higher intake of total energy\u2010adjusted magnesium had a decreased risk of frailty after adjustment for lifestyle factors, medication use and dietary factors. The relative risk (95% confidence interval) for Quintile 5 (Q5) versus Quintile 1 (Q1) was 0.88 (0.82, 0.94) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010trend\u00a0&lt;\u00a00.001). When only energy\u2010adjusted magnesium from the diet was considered, the inverse association was stronger (Q5 vs. Q1: 0.68 [0.56, 0.82];\n                      <jats:italic>P<\/jats:italic>\n                      \u2010trend\u00a0&lt;\u00a00.001). Those reaching the recommended daily allowance (RDA) of magnesium through diet had a 14% (9%, 19%) lower risk of frailty compared with those not meeting the RDA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased intake of foods rich in magnesium was associated with a decreased risk of frailty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13450","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T01:40:14Z","timestamp":1717724414000},"page":"1275-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Total magnesium intake and risk of frailty in older women"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-9616","authenticated-orcid":false,"given":"Ellen A.","family":"Struijk","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine Universidad Aut\u00f3noma de Madrid\u2010IdiPaz  Madrid Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa T.","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Nutrition Simmons University  Boston MA USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike A.","family":"Bischoff\u2010Ferrari","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Aging Research University Hospital Z\u00fcrich and University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Centre on Aging and Mobility University Hospital Z\u00fcrich and Waid City Hospital  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Willett","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston MA USA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lopez\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine Universidad Aut\u00f3noma de Madrid\u2010IdiPaz  Madrid Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health)  Madrid Spain"},{"name":"IMDEA\/Food Institute, CEI UAM\u00a0+\u00a0CSIC  Madrid 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