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This cross\u2010sectional study investigated the independent and interactive associations of PA and SB with physical function and performance throughout the adult life course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 499 community\u2010dwelling adults (63% female) aged 20\u201392\u00a0years, involved in the INSPIRE Human Translational Cohort, were used in this cross\u2010sectional study. Daily time spent on moderate\u2010to\u2010vigorous PA (MVPA, min\/day) and SB (h\/day) was measured with activPAL triaxial accelerometers. Physical function and performance were assessed through the measurement of the 4\u2010m usual gait speed (m\/s), handgrip strength (kg), lower\u2010limb strength (isokinetic knee extension torque, N\u00b7m), estimated lower\u2010limb power (five\u2010time chair\u2010rise test performance, s) and cardiorespiratory fitness (V\u0307O<jats:sub>2<\/jats:sub>max, mL\/kg\/min). Confounder\u2010adjusted multiple linear and curvilinear regressions were performed to investigate how MVPA, SB and their interactions were associated with the physical outcomes (all square root\u2010transformed except gait speed) throughout the adulthood spectrum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interaction analyses revealed that the combination of higher levels of MVPA with lower levels of SB favourably reshaped the negative relationship between handgrip strength and age (age<jats:sup>2<\/jats:sup>\u00a0\u00d7\u00a0SB\u00a0\u00d7\u00a0MVPA: <jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22127E\u201008, SE\u00a0=\u00a03E\u201008, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, higher levels of MVPA were independently associated with an improved age\u2010related profile in gait speed (age<jats:sup>2<\/jats:sup>\u00a0\u00d7\u00a0MVPA: <jats:italic>B<\/jats:italic>\u00a0=\u00a03E\u201006, SE\u00a0=\u00a01E\u201006, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), chair\u2010rise performance (age\u00a0\u00d7\u00a0MVPA: <jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22129E\u201005, SE\u00a0=\u00a04E\u201005, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and V\u0307O<jats:sub>2<\/jats:sub>max (MVPA at 21\u00a0years: <jats:italic>B<\/jats:italic>\u00a0=\u00a03E\u201002, SE\u00a0=\u00a07E\u201003, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05; age\u00a0\u00d7\u00a0MVPA: <jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22125E\u201004, SE\u00a0=\u00a02E\u201004, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Conversely, the detrimental association of age with lower\u2010limb muscle strength (age\u00a0\u00d7\u00a0SB: <jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22121E\u201004, SE\u00a0=\u00a06E\u201005, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and chair\u2010rise performance (age\u00a0\u00d7\u00a0SB: <jats:italic>B<\/jats:italic>\u00a0=\u00a01E\u201005, SE\u00a0=\u00a07E\u201006, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) was exacerbated with increasing duration of SB, independently of MVPA. Supplementary analyses further revealed that some of these associations were age and sex specific.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This cross\u2010sectional study demonstrated that reduced sedentary time and increased activity duration were independently and synergistically associated with an attenuated age\u2010related loss in physical capacity. These findings need to be confirmed with longitudinal data but encourage both adopting an active lifestyle and reducing sedentary time as preventive measures against physical aging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13457","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:40:39Z","timestamp":1713505239000},"page":"1134-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cross\u2010sectional interactive associations of physical activity and sedentary behaviour with physical capacity across adulthood"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-9113","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Raffin","sequence":"first","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myl\u00e8ne","family":"Aubertin\u2010Leheudre","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences de l'activit\u00e9 physique, Facult\u00e9 des sciences Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Canada"},{"name":"Centre de recherche, Institut universitaire de g\u00e9riatrie de Montr\u00e9al (IUGM), CIUSSS du Centre\u2010Sud\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline","family":"Aragoni da Silva","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Pillard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine du Sport, Clinique Universitaire du Sport, H\u00f4pital Pierre Paul RIQUET (Centre Hospitalo\u2010Universitaire)  Toulouse France"},{"name":"Centre RESTORE (Geroscience and Rejuvenation Center), UMR 1301 (INSERM)\/UMR 5070 (CNRS)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire (IHU) HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295, University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the INSPIRE group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Regional Office for South\u2010East Asia. 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