{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:31:59Z","timestamp":1791369119585,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015170","name":"Department of Industry, Science and Resources","doi-asserted-by":"publisher","award":["ICG001874"],"award-info":[{"award-number":["ICG001874"]}],"id":[{"id":"10.13039\/501100015170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Telomere attrition may share common biological mechanisms with bone and muscle loss with aging. Here, we investigated the association between these hallmarks of aging using data from UK Biobank, a large observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Leukocyte telomere length (LTL as T\/S ratio) was measured using a multiplex qPCR assay at baseline (2006\u20132010). Bone mineral density (whole body and regional; via dual\u2010energy X\u2010ray absorptiometry), trabecular bone score (via lumbar\u2010spine dual\u2010energy X\u2010ray absorptiometry images), fat\u2010free muscle volume (thighs; via magnetic resonance imaging), and muscle fat infiltration (thighs; via magnetic resonance imaging) were measured during the imaging visit (2014\u20132018). Regression models were used to model LTL against a muscle or bone outcome, unadjusted and adjusted for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16\u00a0356 adults (mean age: 62.8\u00a0\u00b1\u00a07.5\u00a0years, 50.5% women) were included. In the fully adjusted model, thigh fat\u2010free muscle volume was associated with LTL in the overall sample (adjusted standardized <jats:italic>\u03b2<\/jats:italic> (a<jats:italic>\u03b2<\/jats:italic>)\u00a0=\u00a00.017, 95% CI 0.009 to 0.026, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, per SD increase in LTL), with stronger associations in men (a<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.022, 95% CI 0.010 to 0.034, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than in women (a<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.013, 95% CI 0.000 to 0.025, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.041) (sex\u2010LTL <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028). The adjusted odds ratio (aOR) for low thigh fat\u2010free muscle volume (body mass index\u2010adjusted, sex\u2010specific bottom 20%) was 0.93 per SD increase in LTL (95% CI 0.89 to 0.96, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the overall sample, with stronger associations in men (aOR\u00a0=\u00a00.92, 95% CI 0.87 to 0.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) than women (aOR\u00a0=\u00a00.93, 95% CI 0.88 to 0.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), although the sex difference was not statistically significant in this model (sex\u2010LTL <jats:italic>P<\/jats:italic>\u00a0=\u00a00.37). LTL was not associated with bone mineral density, trabecular bone score, or muscle fat infiltration in the overall or subgroup analyses (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LTL was consistently associated with thigh fat\u2010free muscle volume in men and women. Future research should investigate moderating effects of lifestyle factors (e.g., physical activity, nutrition, or chronic diseases) in the association between LTL and muscle volume.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13461","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T06:01:24Z","timestamp":1711778484000},"page":"1157-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Leukocyte telomere length is associated with MRI\u2010thigh fat\u2010free muscle volume: data from 16 356 UK Biobank adults"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-776X","authenticated-orcid":false,"given":"Ben","family":"Kirk","sequence":"first","affiliation":[{"name":"Department of Medicine, Western Health, Melbourne Medical School University of Melbourne  Melbourne VIC Australia"},{"name":"Australian Institute for Musculoskeletal Science (AIMSS) University of Melbourne and Western Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ling","family":"Kuo","sequence":"additional","affiliation":[{"name":"The Cato T. Laurencin Institute for Translation in Regenerative Engineering University of Connecticut Health  Farmington CT USA"},{"name":"UConn Center on Aging University of Connecticut  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiran","family":"Liu","sequence":"additional","affiliation":[{"name":"The Cato T. Laurencin Institute for Translation in Regenerative Engineering University of Connecticut Health  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiruo","family":"Xiang","sequence":"additional","affiliation":[{"name":"The Cato T. Laurencin Institute for Translation in Regenerative Engineering University of Connecticut Health  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Earp","sequence":"additional","affiliation":[{"name":"UConn Center on Aging University of Connecticut  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatupol","family":"Kositsawat","sequence":"additional","affiliation":[{"name":"UConn Center on Aging University of Connecticut  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Kuchel","sequence":"additional","affiliation":[{"name":"UConn Center on Aging University of Connecticut  Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western Health, Melbourne Medical School University of Melbourne  Melbourne VIC Australia"},{"name":"Australian Institute for Musculoskeletal Science (AIMSS) University of Melbourne and Western Health  Melbourne VIC Australia"},{"name":"Bone, Muscle &amp; Geroscience Group Research Institute of the McGill University Health Centre  Montreal QC Canada"},{"name":"Dr. Joseph Kaufmann Chair in Geriatric Medicine, Department of Medicine McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00599-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-022-01044-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101507"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12326"},{"key":"e_1_2_9_7_1","article-title":"Telomeres shorten at equivalent rates in somatic tissues of adults","volume":"4","author":"Daniali L","year":"2013","journal-title":"Nat Commun"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101942"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20230319"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00842-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116425"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15948-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00166-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163332"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12834"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz229"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.11.031"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090318"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.116806"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.202"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12268"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-022-00706-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4626"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T04:21:48Z","timestamp":1717993308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jcsm.13461"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13461","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,29]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}