{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:45:46Z","timestamp":1785156346351,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to identify the impact of muscle mass on locally advanced oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation therapy (NACRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records of 345 patients diagnosed with LAEC who underwent NACRT and surgery. Physical variables, including height, weight, skeletal muscle mass, and laboratory values, were obtained before and after NACRT. Body mass index (BMI, kg\/m<jats:sup>2<\/jats:sup>), neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were calculated as height\/(weight)<jats:sup>2<\/jats:sup>, ANC\/ALC, platelet count\/ALC, and (10\u00a0\u00d7\u00a0albumin\u00a0+\u00a00.05\u00a0\u00d7\u00a0ALC), respectively. The cutoff for low muscle mass was 43.0\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> for BMI below 25\u00a0kg\/m<jats:sup>2<\/jats:sup> and 53.0\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> for BMI 25\u00a0kg\/m<jats:sup>2<\/jats:sup> or higher. The skeletal muscle index (SMI) was defined as skeletal muscle area\/(height)<jats:sup>2<\/jats:sup> (cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>). The \u0394SMI (%\/50\u00a0days) was defined as (SMI after NACRT\u00a0\u2212\u00a0SMI before NACRT)\/interval (days)\u00a0\u00d7\u00a050 (days) to compare changes over the same period. The excessive muscle loss (EML) group was defined as patients with \u0394SMI \u2264\u221210% following NACRT. An elderly patient was defined as aged \u226565\u00a0years. The primary outcome measure was overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 32.8\u00a0months (range, 2.0\u2013176.2), 192 patients died, with a median OS of 50.2\u00a0months. Elderly patients did not show inferior OS (young vs. elderly, 57.7% vs. 54.0% at 3\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.247). 71.0% and 87.2% of all patients had low muscle mass before and after NACRT, respectively, which was not associated with OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.270 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.509, respectively). Inflammatory (NLR and PLR) and nutritional index (PNI) values or their changes did not correlate with OS. However, the EML group had worse OS (41.6% vs. 63.2% at 3\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). In the multivariate analysis, EML was also a significant prognostic factor for OS. In the subgroup analysis by age, EML was a strong prognostic factor for OS in the elderly group. The 3\u2010year OS was 36.8% in the EML group and 64.9% in the non\u2010EML group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) in elderly patients, and 47.4% and 62.1% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.063) in the young patients. In multivariate analysis of each subgroup, EML remained prognostic only in the elderly group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EML may be strongly associated with a deteriorated OS in elderly patients undergoing NACRT, followed by surgery for LAEC. The strategies for decreasing muscle loss in these patients should be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13462","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T08:30:11Z","timestamp":1712997011000},"page":"1167-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic impact of muscle mass loss in elderly patients with oesophageal cancer receiving neoadjuvant chemoradiation therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-0635","authenticated-orcid":false,"given":"Jeong Yun","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Konkuk University Medical Center Konkuk University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-5519","authenticated-orcid":false,"given":"Dongryul","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Myoung","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Mu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\u2010Oncology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Kwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mog","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul 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