{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:48:10Z","timestamp":1791553690819,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012487","name":"Interdisciplinary Medicine Seed Fund of Peking University","doi-asserted-by":"publisher","award":["104006024"],"award-info":[{"award-number":["104006024"]}],"id":[{"id":"10.13039\/501100012487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lean body mass (LBM) and the functional capacity of cardiovascular (CV) and respiratory systems constitute a female\u2010specific relationship in European\u2013American individuals. Whether this recent finding be extrapolated to the world's largest ethnic group, that is, Hans Chinese (HC, a population characterized by low LBM), is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy HC adults (<jats:italic>n<\/jats:italic>\u00a0=\u00a0144, 50% \u2640) closely matched by sex, age and physical activity were included. Total and regional (leg, arm and trunk) LBM and body composition were measured via dual\u2010energy X\u2010ray absorptiometry. Cardiac structure, stiffness, central\/peripheral haemodynamics and peak O<jats:sub>2<\/jats:sub> consumption (VO<jats:sub>2peak<\/jats:sub>) were assessed via transthoracic echocardiography and pulmonary gas analyses at rest and during exercise up to peak effort. Regression analyses determined the sex\u2010specific relationship of LBM with cardiac and aerobic phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total and regional LBM were lower and body fat percentage higher in women compared with men (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In both sexes, total LBM positively associated with left ventricular (LV) mass and peak volumes (<jats:italic>r<\/jats:italic>\u00a0\u2265\u00a00.33, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.005) and negatively with LV end\u2010systolic and central arterial stiffness (<jats:italic>r<\/jats:italic>\u00a0\u2265\u00a0\u22120.34, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.004). Total LBM strongly associated with VO<jats:sub>2peak<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0\u2265\u00a00.60, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and peak cardiac output (<jats:italic>r<\/jats:italic>\u00a0\u2265\u00a00.40, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in women and men. Among regional LBM, leg LBM prominently associated with the arterio\u2010venous O<jats:sub>2<\/jats:sub> difference at peak exercise in both sexes (<jats:italic>r<\/jats:italic>\u00a0\u2265\u00a00.43, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Adjustment by adiposity or CV risk factors did not modify the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LBM independently determines internal cardiac dimensions, ventricular mass, distensibility and the capacity to deliver and consume O<jats:sub>2<\/jats:sub> in HC adults irrespective of sex.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13464","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T04:15:20Z","timestamp":1713413720000},"page":"963-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lean body mass and the cardiorespiratory phenotype: An ethnic\u2010specific relationship in Hans Chinese women and men"],"prefix":"10.1002","volume":"15","author":[{"given":"Meihan","family":"Guo","sequence":"first","affiliation":[{"name":"Faculty of Medicine Hong Kong University  Hong 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-8271","authenticated-orcid":false,"given":"David","family":"Montero","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hong Kong University  Hong Kong"},{"name":"Department of Medicine, School of Clinical Medicine Hong Kong University  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Human standard and maximal metabolic rate in relation to fat\u2010free body mass","volume":"37","author":"Von Dobeln W","year":"1956","journal-title":"Acta Physiol Scand 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