{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:00:19Z","timestamp":1790791219468,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurogenic dysphagia is a frequent complication of stroke and is associated with aspiration pneumonia and poor outcomes. Although ischaemic lesion location and size are major determinants of the presence and severity of post\u2010stroke dysphagia, little is known about the contribution of other acute stroke\u2010unrelated factors. We aimed to analyse the impact of swallowing and non\u2010swallowing muscles measurements on swallowing function after large vessel occlusion stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was based on a prospective registry of consecutive ischaemic stroke patients. Patients who underwent mechanical thrombectomy between July 2021 and June 2022 and received a flexible endoscopic evaluation of swallowing (FEES) within 5\u00a0days after admission were included. Demographic, anthropometric, clinical, and imaging data were collected from the registry. The cross\u2010sectional areas (CSA) of selected swallowing muscles (as a surrogate marker for swallowing muscle mass) and of cervical non\u2010swallowing muscles were measured in computed tomography. Skeletal muscle index (SMI) was calculated and used as a surrogate marker for whole body muscle mass. FEES parameters, namely, Functional Oral Intake Scale (FOIS, as a surrogate marker for dysphagia presence and severity), penetration aspiration scale, and the presence of moderate\u2010to\u2010severe pharyngeal residues were collected from the clinical records. Univariate and multivariate ordinal and logistic regression analyses were performed to analyse if total CSA of swallowing muscles and SMI were associated with FEES parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final study population consisted of 137 patients, 59 were female (43.1%), median age was 74\u00a0years (interquartile range 62\u201383), median baseline National Institutes of Health Stroke Scale score was 12 (interquartile range 7\u201316), 16 patients had a vertebrobasilar occlusion (11.7%), and successful recanalization was achieved in 127 patients (92.7%). Both total CSA of swallowing muscles and SMI were significantly correlated with age (rho\u00a0=\u00a0\u22120.391,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 and rho\u00a0=\u00a0\u22120.525,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively). Total CSA of the swallowing muscles was independently associated with FOIS (common adjusted odds ratio\u00a0=\u00a01.08, 95% confidence interval\u00a0=\u00a01.01\u20131.16,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.029), and with the presence of moderate\u2010to\u2010severe pharyngeal residues for puree consistencies (adjusted odds ratio\u00a0=\u00a00.90, 95% confidence interval\u00a0=\u00a00.81\u20130.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.036). We found no independent association of SMI with any of the FEES parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline swallowing muscle mass contributes to the pathophysiology of post\u2010stroke dysphagia. Decreasing swallowing muscle mass is independently associated with increasing severity of early post\u2010stroke dysphagia and with increased likelihood of moderate\u2010to\u2010severe pharyngeal residues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13512","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T21:38:42Z","timestamp":1718746722000},"page":"1539-1548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Swallowing muscle mass contributes to post\u2010stroke dysphagia in ischemic stroke patients undergoing mechanical thrombectomy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-7146","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pinho","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Schumann\u2010Werner","sequence":"additional","affiliation":[{"name":"Department of Neurology and Geriatrics Johanniter Hospital Stendal GmbH  Stendal Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research Otto Von Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Tauber","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Nikoubashman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wiesmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital RWTH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius J.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen Germany"},{"name":"Department of Neurology and Geriatrics Johanniter Hospital Stendal GmbH  Stendal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH  Aachen 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