{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:24:39Z","timestamp":1791563079656,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052826"],"award-info":[{"award-number":["NNF18OC0052826"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growth differentiation factor\u201015 (GDF\u201015) has been associated with senescence, lower muscle strength, and physical performance in healthy older people. Still, it is not clear whether GDF\u201015 can be utilized as a biomarker of sarcopenia and frailty in the early stages of hospitalization. We investigated the association of plasma GDF\u201015 with sarcopenia and frailty in older, acutely admitted medical patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study is based on secondary analyses of cross\u2010sectional data from the Copenhagen PROTECT study, a prospective cohort study including 1071 patients \u226565\u00a0years of age admitted to the acute medical ward at Copenhagen University Hospital, Bispebjerg, Denmark. Muscle strength was assessed using handgrip strength, and lean mass was assessed using direct segmental multifrequency bioelectrical impedance analyses and used to clarify the potential presence of sarcopenia defined according to guidelines from the European Working Group on Sarcopenia in Older People. Frailty was evaluated using the Clinical Frailty Scale. Plasma GDF\u201015 was measured using electrochemiluminescence assays from Meso Scale Discovery (MSD, Rockville, MD, USA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1036 patients with completed blood samples (mean age 78.9\u00a0\u00b1\u00a07.8\u00a0years, 53% female). The median concentration of GDF\u201015 was 2669.3\u00a0pg\/mL. Systemic GDF\u201015 was significantly higher in patients with either sarcopenia (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) or frailty (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with patients without the conditions. Optimum cut\u2010off points of GDF\u201015 relating to sarcopenia and frailty were 1541 and 2166\u00a0pg\/mL, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systemic GDF\u201015 was higher in acutely admitted older medical patients with sarcopenia and frailty compared with patients without. The present study defined the optimum cut\u2010off for GDF\u201015, related to the presence of sarcopenia and frailty, respectively. When elevated above the derived cutoffs, GDF\u201015 was strongly associated with frailty and sarcopenia in both crude and fully adjusted models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13513","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T23:59:30Z","timestamp":1718755170000},"page":"1549-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["GDF\u201015 is associated with sarcopenia and frailty in acutely admitted older medical patients"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-9078","authenticated-orcid":false,"given":"Rikke S.","family":"Kamper","sequence":"first","affiliation":[{"name":"Department of Geriatric &amp; Palliative Medicine Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"CopenAge, Copenhagen Center for Clinical Age Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Geriatric &amp; 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