{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:19:20Z","timestamp":1790389160655,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2022R1A5A2018865"],"award-info":[{"award-number":["2022R1A5A2018865"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1I1A3072966"],"award-info":[{"award-number":["2022R1I1A3072966"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010haemodialysis (HD) serum creatinine levels are reliable and inexpensive markers of muscle mass and important predictors of survival in patients with stable chronic HD. We aimed to assess whether changes in pre\u2010HD serum creatinine levels during a 2\u2010year period are linked to long\u2010term patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed patients enrolled in a periodic HD quality assessment program. Of the 21\u00a0846 participants in the fourth HD quality assessment program, 13\u00a0765 were presented in the fifth, of which 10\u00a0299 eligible patients were included in this study. We assessed the change in serum creatinine levels over 2\u00a0years. The patients were categorized into the following three groups: stable group (patients with change in serum creatinine\u00a0&lt;\u00a01\u00a0mg\/dL during 2\u00a0years of HD, <jats:italic>n<\/jats:italic>\u00a0=\u00a05664), increasing group (patients with increase in serum creatinine\u00a0\u2265\u00a01\u00a0mg\/dL, <jats:italic>n<\/jats:italic>\u00a0=\u00a02419) and decreasing group (patients with decrease in serum creatinine\u00a0\u2265\u00a01\u00a0mg\/dL, <jats:italic>n<\/jats:italic>\u00a0=\u00a02216).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The duration of HD at baseline was 62\u201383\u00a0months, with diabetic kidney disease being the most common cause of kidney failure in 36.4% of patients. The 5\u2010year patient survival rates in the stable, increasing and decreasing groups were 69.1%, 71.3% and 66.8%, respectively. The decreasing group had poorer patient survival than the other two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.083 for stable vs. increasing group; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011 for stable vs. decreasing group; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for increasing vs. decreasing group). There was no significant difference in the cardiovascular event\u2010free survival rate among the three groups. Multivariable Cox regression analyses revealed the highest hazard ratio (HR) for mortality in the decreasing group (HR 1.33, 95% confidence interval [CI] 1.21\u20131.45, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 vs. stable group; HR 1.50, 95% CI 1.34\u20131.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 vs. increasing group). The increasing group exhibited a lower risk of mortality than the stable group (HR 0.88, 95% CI 0.81\u20130.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Subgroup analyses based on age, HD vintage, sex, Charlson comorbidity index score, presence of diabetes and baseline serum creatinine level tertiles revealed that the decreasing group exhibited the highest mortality among all subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that changes in pre\u2010HD serum creatinine levels over 2\u00a0years of HD were associated with all\u2010cause mortality in patients undergoing HD. This finding suggests a simple and promising approach for clinicians in the prognosis and management of patients undergoing HD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13515","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T05:39:50Z","timestamp":1718775590000},"page":"1568-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in pre\u2010haemodialysis serum creatinine levels over 2\u00a0years and long\u2010term survival in maintenance haemodialysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-0195","authenticated-orcid":false,"given":"Seok Hui","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Yeungnam University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Insurance Review and Assessment Service  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Insurance Review and Assessment Service  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Son","sequence":"additional","affiliation":[{"name":"Health Insurance Review and Assessment Service  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Young","family":"Do","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Yeungnam University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"US Renal Data System.USRDS 2020 Annual Data Report: Atlas of Chronic Kidney Disease in the United States National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Bethesda MD.2020. 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American Society of Nephrology. Kidney Week October 31\u2013November 5 2017 New Orleans LA."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002585"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.15263\/jlmqa.2023.45.1.10"},{"key":"e_1_2_9_26_1","unstructured":"ESRD Registry Committee: Korean Society of Nephrology.Current renal replacement therapy in Korea[cited 2024 Apr 2]. Available from:https:\/\/ksn.or.kr\/bbs\/index.php?code=report."}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:55:55Z","timestamp":1722567355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jcsm.13515"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13515","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}