{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:03:42Z","timestamp":1785240222485,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the predictive capacity of lymphocyte subpopulations, sarcopenia and myosteatosis for clinical outcomes in patients who underwent gastric cancer surgery. Additionally, the prognostic significance of CD3+\/CD4+ cells in conjunction with myosteatosis was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 190 patients with gastric cancer who underwent surgery and received computed tomography scans between July 2016 and December 2017 at our institution was examined. Complete clinical information and peripheral lymphocyte subpopulations were available for all patients. A comprehensive array of statistical methodologies was employed to scrutinize variances in both clinical and pathological characteristics among patients, with the aim of identifying autonomous prognostic determinants requisite for the development of a nomogram. Subsequent assessment of the predictive efficacy of the nomogram was conducted via calibration curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised a cohort of 190 participants, encompassing 126 males (66.32%) and 64 females (33.68%), with a mean age of 58.47 (\u00b111.37) years. Patients were stratified into three groups based on CD3+\/CD4+ cells and myosteatosis, with 24 in Group 1, 87 in Group 2 and 79 in Group 3. Notably, patients in the third group exhibited significantly shorter progression\u2010free survival (PFS) (hazard ratio [HR]\u00a0=\u00a00.208, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and overall survival (OS) (HR\u00a0=\u00a00.193, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The subset of peripheral blood lymphocytes exhibited elevated levels of CD3+\/CD4+ cells (HR\u00a0=\u00a02.485, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and heightened CD4+\/CD8+ ratios (HR\u00a0=\u00a01.705, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038), whereas diminished CD19+ cell counts (HR\u00a0=\u00a00.210, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032) correlated with improved OS in patients. The individuals presenting with sarcopenia (HR\u00a0=\u00a04.089, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023) and myosteatosis (HR\u00a0=\u00a02.857, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) displayed reduced OS. The multivariate Cox regression analysis showed that pathological tumour\u2013node\u2013metastasis stage, CD19+ cells, sarcopenia and CD3+\/CD4+ cell\u2013myosteatosis were identified as independent prognostic factors for PFS and OS in patients. The constructed nomograms for PFS and OS yielded C\u2010index values of 0.839 (95% confidence interval [CI]: 0.798\u20130.880) and 0.836 (95% CI: 0.792\u20130.879), respectively. The calibration analysis demonstrated that the nomograms accurately predicted the 3\u2010 and 5\u2010year survival rates of PFS and OS in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymphocyte subsets, including CD3+\/CD4+ cells, CD4+\/CD8+ ratio and CD19+ cells, are indicative of clinical prognosis in gastric cancer surgery patients. Body composition parameters, such as sarcopenia and myosteatosis, are also associated with the patient's prognosis. The combination of CD3+\/CD4+ cells with myosteatosis demonstrates enhanced prognostic value, enabling the identification of patients at high risk of post\u2010operative metastasis and recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13517","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T05:39:58Z","timestamp":1718775598000},"page":"1587-1600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CD3+\/CD4+ cells combined with myosteatosis predict the prognosis in patients who underwent gastric cancer surgery"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-6072","authenticated-orcid":false,"given":"Zhongze","family":"Du","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital, Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youming","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery YaAn People's Hospital  Ya'an Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiming","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital, Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital, Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital, Harbin Medical 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