{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:31:15Z","timestamp":1790616675073,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2023, the concept of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) was introduced as an alternative to non\u2010alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 18\u00a0154 participants (11\u00a0551 [63.6%] men and 6603 [36.4%] women, mean age 53.0\u00a0\u00b1\u00a08.8). The participants were classified into four categories: neither steatotic liver disease (SLD), NAFLD only, MASLD only or both SLDs. An appendicular skeletal muscle mass adjusted for body mass index of &lt;0.789 for men and &lt;0.512 for women was defined as sarcopenia. The total abdominal muscle area (TAMA) at the L3 vertebral level was segmented into normal\u2010attenuation muscle area (NAMA), low\u2010attenuation muscle area and intermuscular\/intramuscular adipose tissue. Myosteatosis was defined by a T\u2010score\u00a0&lt;\u00a0\u22121.0 of the NAMA\/TAMA index, which was calculated by dividing the NAMA by the TAMA and multiplying by 100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using subjects with neither SLD as a reference, the multivariable\u2010adjusted odds ratios (ORs) for sarcopenia were significantly increased in those with MASLD, with adjusted ORs (95% confidence interval [CI]) of 2.62 (1.94\u20133.54) in the MASLD\u2010only group and 2.33 (1.92\u20132.82) in the both SLDs group, while the association was insignificant in those with NAFLD only (adjusted OR [95% CI]: 2.16 [0.67\u20136.94]). The OR for myosteatosis was also elevated in the MASLD groups, with an OR (95% CI) of 1.75 (1.52\u20132.02) in subjects with MASLD only and 1.70 (1.57\u20131.84) in those with both SLDs, while it was slightly decreased in subjects with NAFLD only (0.52 [0.29\u20130.95]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Employing the MASLD concept rather than that of the NAFLD proved to be more effective in distinguishing individuals with reduced muscle mass and compromised muscle quality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13543","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:38:05Z","timestamp":1721122685000},"page":"1942-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between metabolic dysfunction\u2010associated steatotic liver disease and myosteatosis measured by computed tomography"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3485-1879","authenticated-orcid":false,"given":"Myung Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Asan Diabetes Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-1376","authenticated-orcid":false,"given":"Yun Kyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Asan Diabetes Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-9693","authenticated-orcid":false,"given":"Woo Je","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Asan Diabetes Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-3521","authenticated-orcid":false,"given":"Hong\u2010Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4043-2396","authenticated-orcid":false,"given":"Chang Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Asan Diabetes Center Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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