{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:44:20Z","timestamp":1793951060909,"version":"4.8.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309200"],"award-info":[{"award-number":["2017YFC1309200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Asian Working Group for Cachexia (AWGC) proposed the first consensus report on diagnostic criteria for cachexia in Asians in 2023. However, the current consensus lacks cohort evidence to validate its effectiveness and practicality. We aimed to explore the value of the AWGC2023 criteria for predicting the prognosis and medical burden of patients with cancer through a retrospective post hoc cross\u2010sectional analysis of the Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) project in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cox regression analyses were performed to assess the independent association between cachexia and long\u2010term survival. We utilized C\u2010reactive protein (CRP), neutrophil\u2010to\u2010lymphocyte ratio (NLR), inflammatory burden index (IBI), albumin (ALB) and Glasgow prognostic score (GPS) as diagnostic markers for cachexia, designating them as CRP\u2010based cachexia, NLR\u2010based cachexia, IBI\u2010based cachexia, ALB\u2010based cachexia and GPS\u2010based cachexia, respectively. Additionally, we diagnosed cachexia using body mass index (BMI) cutoff values of 18.5, 20, 21 and 22\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively, and subsequently compared their prognostic predictive value through Harrell's concordance index (C\u2010index). Logistic regression models were used to assess the association between cachexia and medical burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5426 patients with cancer were enrolled in this study. Cox regression analysis confirmed that cachexia based on the AWGC2023 criteria was an independent predictor of long\u2010term survival in patients with cancer. Patients with cachexia had significantly poorer long\u2010term survival than patients without cachexia (66.4% vs. 49.7%, P\u00a0&lt;\u00a00.001). Inflammatory biomarker\u2010based cachexia was as an independent predictor of prognosis in patients with cancer, with inflammatory burden index (IBI)\u2010based cachexia demonstrating the optimal prognostic discriminatory ability. The C\u2010index indicated that cachexia based on BMI cutoff values of 18.5, 20, and 22\u00a0kg\/m<jats:sup>2<\/jats:sup> did not perform as well as a BMI cutoff value of 21\u00a0kg\/m<jats:sup>2<\/jats:sup>. Logistic regression models revealed that using the AWGC2023 criteria, patients with cachexia had a 16.6% higher risk of prolonged hospitalization and a 16.0% higher risk of high medical expenses than patients without cachexia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The AWGC2023 criteria represent a valuable tool for predicting survival and medical burden among Chinese patients with cancer. Encouragement for further validation in other Asian populations is warranted for the AWGC2023 criteria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13555","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T05:20:06Z","timestamp":1724822406000},"page":"2084-2093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["AWGC2023 cachexia consensus as a valuable tool for predicting prognosis and burden in Chinese patients with cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Hailun","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Gland Surgery, First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Gland Surgery, First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotian","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing 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