{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:41:22Z","timestamp":1793205682385,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Uric acid (UA), the terminal breakdown product of purine metabolism, possesses contradictory roles, functioning both as an inflammatory mediator and as an antioxidant. Its clinical relevance, particularly in geriatric populations, remains a topic of ongoing debate. Aiming to elucidate whether circulating UA is detrimental or beneficial to human health, we investigate the association between serum UA concentrations and the frailty index\u2014a comprehensive measure of biological aging in a nationally representative cohort of community\u2010dwelling older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based, cross\u2010sectional study utilizing data from the Korea National Health and Nutrition Examination Survey. The sample included 4268 participants aged 65\u00a0years and above. A deficit accumulation frailty index (FI) was constructed using 38 items that assess physical, cognitive, psychological, and social domains. Based on the FI, participants were categorized into non\u2010frail (FI\u00a0\u2264\u00a00.15), pre\u2010frail (0.15\u00a0&lt;\u00a0FI\u00a0\u2264\u00a00.25), or frail (FI\u00a0&gt;\u00a00.25). Serum UA levels were quantified through a colorimetric enzymatic assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for confounders such as age, sex, socioeconomic status (including income and education level), lifestyle factors (smoking status), and medical history (hypertension, diabetes, dyslipidemia, stroke, cardiovascular diseases), and body mass index, serum UA levels were observed to be significantly higher in frail participants compared with their non\u2010frail counterparts (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Furthermore, serum UA concentrations demonstrated a positive correlation with the FI (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the odds ratio for frailty per 1\u00a0mg\/dL increase in serum UA was 1.22 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Additionally, older adults in the highest quartile of UA levels exhibited a significantly higher FI and 1.66\u2010fold increased odds of frailty compared with those in the lowest quartile (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that elevated circulating UA levels may act as a pro\u2010aging factor rather than an anti\u2010aging one in older adults, highlighting its potential role in accelerating biological aging. The data further support the utility of serum UA as a potential blood\u2010based biomarker for frailty in this demographic, contributing to the expanding evidence on its significance in geriatric health assessments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13561","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:19:02Z","timestamp":1724026742000},"page":"2134-2142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population\u2010based study"],"prefix":"10.1002","volume":"15","author":[{"given":"Min\u2010gu","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Bitgoeul Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunju","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongryeol","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il\u2010Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-1759","authenticated-orcid":false,"given":"Beom\u2010Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Asan Medical Center University of Ulsan College of Medicine  Seoul South 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