{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:42Z","timestamp":1791388902733,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2010117302RA\u2010I00"],"award-info":[{"award-number":["PID2020\u2010117302RA\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["LCF\/BQ\/PR19\/11700007"],"award-info":[{"award-number":["LCF\/BQ\/PR19\/11700007"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia and low areal bone mineral density (aBMD) are prevalent musculoskeletal complications after paediatric cancer treatment. However, their relationship has not been examined in young paediatric cancers survivors. This study aimed to evaluate aBMD differences according to sarcopenia status and the risk of low aBMD <jats:italic>Z<\/jats:italic>\u2010score in young paediatric cancer survivors with sarcopenia confirmed\/probable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 116 paediatric cancer survivors (12.1\u00a0\u00b1\u00a03.3\u00a0years old; 42.2% female). Handgrip strength was used to assessed muscle strength. Dual\u2010energy X\u2010ray absorptiometry estimated aBMD (g\/cm<jats:sup>2<\/jats:sup>) and appendicular lean mass index (ALMI, kg\/m<jats:sup>2<\/jats:sup>). \u2018No sarcopenia\u2019 was defined when muscle strength was &gt;decile 2. \u2018Sarcopenia probable\u2019 was defined when muscle strength was \u2264 decile 2 and ALMI Z\u2010score was &gt; \u22121.5 standard deviation (SD). \u2018Sarcopenia confirmed\u2019 was defined when muscle strength was \u2264 decile 2 and ALMI <jats:italic>Z<\/jats:italic>\u2010score \u2264 \u22121.5 SD. Analysis of covariance and logistic regression, adjusted for time from treatment completion, radiotherapy exposure, calcium intake, and physical activity, was used to evaluate aBMD and estimate the odds ratios (ORs) of low aBMD (aBMD <jats:italic>Z<\/jats:italic>\u2010score &lt; \u22121.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survivors with sarcopenia confirmed had significantly lower aBMD than those without sarcopenia at total body (\u22121.2 [95% CI: \u22121.5 to \u22120.8] vs. 0.2 [\u22120.2 to 0.6], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), lumbar spine (\u22120.7 [\u22121.1 to \u22120.3] vs. 0.4 [0.0 to 0.8], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), total hip (\u22120.5 [\u22120.9 to \u22120.2] vs. 0.4 [0.1 to 0.8], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and femoral neck (\u22121.0 [\u22121.4 to \u22120.6] vs. 0.1 [\u22120.3 to 0.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Compared with survivors with sarcopenia probable, survivors with sarcopenia confirmed had significantly lower aBMD <jats:italic>Z<\/jats:italic>\u2010score at total body (\u22121.2 [\u22121.5 to \u22120.8] vs. \u22120.2 [\u22120.7 to 0.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), total hip (\u22120.5 [\u22120.9 to \u22120.2] vs. 0.5 [\u22120.1 to 1.0], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010), and femoral neck (\u22121.0 [\u22121.4 to \u22120.6] vs. 0.1 [\u22120.5 to 0.7], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014). Survivors with sarcopenia confirmed were at higher risk of low aBMD <jats:italic>Z<\/jats:italic>\u2010score at the total body (OR: 6.91, 95% CI: 2.31\u201324.15), total hip (OR: 2.98, 1.02\u20139.54), and femoral neck (OR: 4.72, 1.72\u201314.19), than those without sarcopenia. Survivors with sarcopenia probable were at higher risk of low aBMD <jats:italic>Z<\/jats:italic>\u2010score at the total body (OR: 4.13, 1.04\u201317.60) than those without sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young paediatric cancer survivors with sarcopenia present higher risk of low aBMD. Resistance training\u2010based interventions designed to mitigate osteosarcopenia in this population should be implemented at early stages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13563","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:33:54Z","timestamp":1724294034000},"page":"2156-2163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Co\u2010morbid sarcopenia and low bone mineral density in young paediatric cancer survivors"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1828-4614","authenticated-orcid":false,"given":"Andres","family":"Marmol\u2010Perez","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-2399","authenticated-orcid":false,"given":"Esther","family":"Ubago\u2010Guisado","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Biosanitary Research Institute  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.","family":"Gil\u2010Cosano","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Department of Communication and Education Loyola University Andalusia  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Llorente\u2010Cantarero","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC)  Cordoba Spain"},{"name":"Department of Specific Didactics, Faculty of Education University of Cordoba  Cordoba Spain"},{"name":"CIBEROBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Pascual\u2010G\u00e1zquez","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Hematology and Oncology Service, Pediatrics and Pediatric Surgery Clinical Management Unit Virgen de las Nieves University Hospital  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mu\u00f1oz\u2010Torres","sequence":"additional","affiliation":[{"name":"Biosanitary Research Institute  Granada Spain"},{"name":"Endocrinology and Nutrition Unit Hospital Universitario San Cecilio  Granada Spain"},{"name":"Department of Medicine, Faculty of Medicine University of Granada  Granada Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERfes) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Martinez\u2010Vizcaino","sequence":"additional","affiliation":[{"name":"Health and Social Research Center Universidad de Castilla\u2010La Mancha  Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBEROBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition Carlos III Health Institute  Madrid Spain"},{"name":"Biosanitary Research Institute  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Gracia\u2010Marco","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBEROBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition Carlos III Health Institute  Madrid Spain"},{"name":"Biosanitary Research Institute  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz120"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01917"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3268"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2020.08.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aac2.12027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-023-00760-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0052-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169548"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.04.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.2268"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4384-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00020-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09607-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00102"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00064.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000588"},{"key":"e_1_2_9_19_1","first-page":"1773","article-title":"Validity of a food\u2010frequency questionnaire for estimating calcium intake in adolescent swimmers","volume":"32","author":"Juli\u00e1n Alm\u00e1rcegui C","year":"2015","journal-title":"Nutr Hosp"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142533","article-title":"A novel, open access method to assess sleep duration using a wrist\u2010worn accelerometer","volume":"10","author":"Hees VT","year":"2015","journal-title":"PLoS ONE"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022922"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12795"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001435"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2019.07.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556113"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1111"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.08.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17218026"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106176"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520380029031"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.12.039"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02645-8"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa213"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020383"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2388-9"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318279eea2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.10.048"},{"key":"e_1_2_9_39_1","first-page":"3","article-title":"Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors: the iBoneFIT project","volume":"24","author":"Marmol\u2010Perez A","year":"2024","journal-title":"J Sport Health Sci"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12734"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12899"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T02:48:11Z","timestamp":1727923691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jcsm.13563"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13563","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"2024-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}